We demonstrate the use of a probabilistic generative model to explore the biomarker
changes occurring as Alzheimer's disease develops and progresses. We enhanced the …

Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) is an ongoing,
longitudinal, multicenter study designed to develop clinical, imaging, genetic, and …

A major sex difference in Alzheimer's disease (AD) is that men with the disease die earlier
than do women. In aging and preclinical AD, men also show more cognitive deficits. Here …

Biobanks and archived data sets collecting samples and data have become crucial engines
of genetic and genomic research. Unresolved, however, is what responsibilities biobanks …

Background Reduced 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET)
brain metabolism was recognized as a biomarker of neurodegeneration in the recently …

Objectives: To determine whether genotypes at CLU, PICALM, and CR1 confer risk for
Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced …

Alzheimer's disease is biologically heterogeneous, and detailed understanding of the
processes involved in patients is critical for development of treatments. CSF contains …

Advances in genetic and genomic technologies over the last thirty years have greatly
enhanced our knowledge concerning the genetic architecture of Alzheimer's disease (AD) …

The discovery of causative genetic mutations in affected family members has historically
dominated our understanding of neurodegenerative diseases such as Alzheimer's disease …

Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) is an ongoing,
longitudinal, multicenter study designed to develop clinical, imaging, genetic, and …