Genome-wide association study of Alzheimer's disease
In addition to apolipoprotein E (APOE), recent large genome-wide association studies
(GWASs) have identified nine other genes/loci (CR1, BIN1, CLU, PICALM, MS4A4/MS4A6E …
(GWASs) have identified nine other genes/loci (CR1, BIN1, CLU, PICALM, MS4A4/MS4A6E …
Convergence of miRNA expression profiling, α-synuclein interacton and GWAS in Parkinson's disease
M Martins, A Rosa, LC Guedes, BV Fonseca… - PloS one, 2011 - journals.plos.org
miRNAs were recently implicated in the pathogenesis of numerous diseases, including
neurological disorders such as Parkinson's disease (PD). miRNAs are abundant in the …
neurological disorders such as Parkinson's disease (PD). miRNAs are abundant in the …
Basal forebrain volume reliably predicts the cortical spread of Alzheimer's degeneration
Alzheimer's disease neurodegeneration is thought to spread across anatomically and
functionally connected brain regions. However, the precise sequence of spread remains …
functionally connected brain regions. However, the precise sequence of spread remains …
A comprehensive genetic association study of Alzheimer disease in African Americans
Objectives To evaluate the association of genetic variation with late-onset Alzheimer
disease (AD) in African Americans, including genes implicated in recent genome-wide …
disease (AD) in African Americans, including genes implicated in recent genome-wide …
Transfer learning approaches for neuroimaging analysis: a scoping review
Deep learning algorithms have been moderately successful in diagnoses of diseases by
analyzing medical images especially through neuroimaging that is rich in annotated data …
analyzing medical images especially through neuroimaging that is rich in annotated data …
APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern
Introduction This study assessed apolipoprotein E (APOE) ε4 carrier status effects on
Alzheimer's disease imaging and cerebrospinal fluid (CSF) biomarkers in cognitively normal …
Alzheimer's disease imaging and cerebrospinal fluid (CSF) biomarkers in cognitively normal …
Longitudinal MRI atrophy biomarkers: relationship to conversion in the ADNI cohort
Atrophic changes in early Alzheimer's disease (AD) and amnestic mild cognitive impairment
(MCI) have been proposed as biomarkers for detection and monitoring. We analyzed …
(MCI) have been proposed as biomarkers for detection and monitoring. We analyzed …
HYDRA: Revealing heterogeneity of imaging and genetic patterns through a multiple max-margin discriminative analysis framework
Multivariate pattern analysis techniques have been increasingly used over the past decade
to derive highly sensitive and specific biomarkers of diseases on an individual basis. The …
to derive highly sensitive and specific biomarkers of diseases on an individual basis. The …
Coding mutations in SORL1 and Alzheimer disease
BN Vardarajan, Y Zhang, JH Lee, R Cheng… - Annals of …, 2015 - Wiley Online Library
Objective Common single nucleotide polymorphisms in the SORL1 gene have been
associated with late onset Alzheimer disease (LOAD), but causal variants have not been …
associated with late onset Alzheimer disease (LOAD), but causal variants have not been …
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study
Deposition of amyloid-β (Aβ) in the cerebral cortex is thought to be a pivotal event in
Alzheimer's disease (AD) pathogenesis with a significant genetic contribution. Molecular …
Alzheimer's disease (AD) pathogenesis with a significant genetic contribution. Molecular …