Motivation: Recent advances in brain imaging and high-throughput genotyping techniques
enable new approaches to study the influence of genetic and anatomical variations on brain …

Imaging traits provide a powerful and biologically relevant substrate to examine the
influence of genetics on the brain. Interest in genome-wide, brain-wide search for influential …

Background Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease
impacting an estimated 44 million adults worldwide. The causal pathology of AD …

Introduction Traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) have
previously been reported to be associated with increased risk of Alzheimer's disease (AD) …

Objective To identify cognitively normal individuals at risk of Alzheimer disease (AD) based
on cerebrospinal fluid (CSF) Aβ1‐42, and to determine rates of cerebral atrophy. Methods …

Background: Elevated blood pressure variability (BPV) is predictive of dementia,
independent of average blood pressure levels, but neuropathological mechanisms remain …

The underlying genetic etiology of late onset Alzheimer's disease (LOAD) remains largely
unknown, likely due to its polygenic architecture and a lack of sophisticated analytic …

Genome-wide association studies have identified dozens of loci that alter the risk to develop
Alzheimer's disease. However, with the exception of the APOE-ε4 allele, most variants bear …

Background Recent studies suggest that plasma phosphorylated tau181 (p-tau181) is a
highly specific biomarker for Alzheimer's disease (AD)-related tau pathology. It has great …

Background Alzheimer disease (AD) is a progressive disorder that affects cognitive function.
There is increasing support for the role of neuroinflammation and aberrant immune …