Relationships among cortical glutathione levels, brain amyloidosis, and memory in healthy older adults investigated in vivo with 1H-MRS and Pittsburgh compound-B …
GC Chiang, X Mao, G Kang, E Chang… - American Journal …, 2017 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Oxidative stress has been implicated as an important
pathologic mechanism in the development of Alzheimer disease. The purpose of this study …
pathologic mechanism in the development of Alzheimer disease. The purpose of this study …
Atrophy of hippocampal subfields and amygdala nuclei in subjects with mild cognitive impairment progressing to Alzheimer's disease
The hippocampus and amygdala are the first brain regions to show early signs of
Alzheimer's Disease (AD) pathology. AD is preceded by a prodromal stage known as Mild …
Alzheimer's Disease (AD) pathology. AD is preceded by a prodromal stage known as Mild …
Visit-to-visit blood pressure variability and subthreshold depressive symptoms in older adults
Objectives Depression is related to increased risk for dementia, possibly through links with
cerebrovascular disease. Blood pressure variability is an emerging risk factor for …
cerebrovascular disease. Blood pressure variability is an emerging risk factor for …
Exercise prevents obesity-induced cognitive decline and white matter damage in mice
LC Graham, WA Grabowska, Y Chun, SL Risacher… - Neurobiology of …, 2019 - Elsevier
Obesity in the western world has reached epidemic proportions, and yet the long-term
effects on brain health are not well understood. To address this, we performed …
effects on brain health are not well understood. To address this, we performed …
Metabolomic and lipidomic signatures in autosomal dominant and late‐onset Alzheimer's disease brains
BC Novotny, MV Fernandez, C Wang… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction The identification of multiple genetic risk factors for Alzheimer's disease (AD)
suggests that many pathways contribute to AD onset and progression. However, the …
suggests that many pathways contribute to AD onset and progression. However, the …
From phenotype to genotype: an association study of longitudinal phenotypic markers to Alzheimer's disease relevant SNPs
Motivation: Imaging genetic studies typically focus on identifying single-nucleotide
polymorphism (SNP) markers associated with imaging phenotypes. Few studies perform …
polymorphism (SNP) markers associated with imaging phenotypes. Few studies perform …
Analysis of copy number variation in Alzheimer's disease: the NIALOAD/NCRAD Family Study
Copy number variants (CNVs) are DNA regions that have gains (duplications) or losses
(deletions) of genetic material. CNVs may encompass a single gene or multiple genes and …
(deletions) of genetic material. CNVs may encompass a single gene or multiple genes and …
Machine learning based multimodal neuroimaging genomics dementia score for predicting future conversion to alzheimer's disease
Background: The increasing availability of databases containing both magnetic resonance
imaging (MRI) and genetic data allows researchers to utilize multimodal data to better …
imaging (MRI) and genetic data allows researchers to utilize multimodal data to better …
Single-nucleotide polymorphisms are associated with cognitive decline at Alzheimer's disease conversion within mild cognitive impairment patients
Introduction The growing public threat of Alzheimer's disease (AD) has raised the urgency to
quantify the degree of cognitive decline during the conversion process of mild cognitive …
quantify the degree of cognitive decline during the conversion process of mild cognitive …
Bridging integrator 1 (BIN1) genotypes mediate Alzheimer's disease risk by altering neuronal degeneration
HF Wang, Y Wan, XK Hao, L Cao… - Journal of …, 2016 - content.iospress.com
Background: Bridging integrator 1 (BIN1) has been identified as one of the most associated
loci for Alzheimer's disease (AD), and recently was reported to modulate tau pathology to …
loci for Alzheimer's disease (AD), and recently was reported to modulate tau pathology to …