Most cancer deaths are due to the development of metastases, hence the most important
improvements in morbidity and mortality will result from prevention (or elimination) of such …

Metastasis, the process by which cancer cells leave the primary tumour, disseminate and
form secondary tumours at anatomically distant sites, is a serious clinical problem as it is …

Novel antiangiogenic strategies with complementary mechanisms are needed to maximize
efficacy and minimize resistance to current angiogenesis inhibitors. We explored the …

Angiogenesis, the formation of new blood vessels from pre-existing vasculature, plays a vital
role in physiological and pathological processes (embryonic development, wound healing …

The concept of inhibiting tumor neovessels has taken the hurdle from the bench to the
bedside and now represents an extra pillar of anticancer treatment. So far, anti-angiogenic …

purpose. Vascular endothelial growth factor (VEGF) antagonists are the therapy of choice for
age-related macular degeneration. Ranibizumab and pegaptanib have been approved by …

The aim of the present study was to investigate the available literature regarding the oral
side effects or adverse events associated with targeted cancer therapy. Common oral …

Angiogenesis affects both wound healing and malignant cell growth through nutrients and
oxygen. Vascular endothelial growth factor (VEGF) is the most important element involved in …

Inhibitors of angiogenesis and radiation induce compensatory changes in the tumor
vasculature both during and after treatment cessation. To assess the responses to irradiation …

Despite improvements in prevention and management of colorectal cancer (CRC),
uncontrolled tumor growth with metastatic spread to distant organs remains an important …