The pronounced daily variation in the release of adrenal hormones has been at the heart of
the deciphering and understanding of the circadian timing system. Indeed, the first …

Compelling data has been amassed indicating that soluble factors, or cytokines, emanating
from the immune system can have profound effects on the neuroendocrine system, in …

The mammalian suprachiasmatic nuclei (SCN) contain an endogenous pacemaker that
generates daily rhythms in behavior and secretion of hormones. We hypothesized that the …

In this review we have argued that corticosteroid hormones represent an endocrine signal
that can influence neuronal communication. The steroids bind to intracellular receptors in …

The hypothalamic-pituitary-adrenal (HPA) axis is an extremely sensitive physiological
system whose activation, with the consequent release of ACTH and glucocorticoids, is …

Depression is potentially life-threatening. The most important neuroendocrine abnormality in
this disorder is hypothalamo-pituitary-adrenocortical (HPA) axis hyperactivity. Recent …

Perhaps the most salient behaviors that individuals engage in involve the avoidance of
aversive experiences and the pursuit of pleasurable experiences. Engagement in these …

Circadian rhythms govern a multitude of physiologic processes, both on a cell-intrinsic level
and systemically, through the coordinated function of multi-organ biosystems. One such …

Elevated cortisol evidence in Alzheimer's disease (AD) patients prompted the hypothesis
that stress and glucocorticoids are involved in the development and/or maintenance of AD …

An ultradian rhythm in adrenal secretion of corticosterone has been described in awake rats
using intra-adrenal microdialysis. To determine the role of the autonomic innervation of the …