Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

Combination chemotherapy is widely exploited for enhanced cancer treatment in the clinic.
However, the traditional cocktail administration of combination regimens often suffers from …

Mechanical force controls fundamental cellular processes in health and disease, and
increasing evidence shows that the nucleus both experiences and senses applied forces …

Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

Nanotechnology makes use of the special surface properties of extremely small particles. In
this rapidly growing field, many different materials are produced for a multitude of diverse …

Importin β family transport receptors shuttle between the nucleus and the cytoplasm and
mediate transport of macromolecules through nuclear pore complexes (NPCs). The …

GSK-3β-dependent phosphorylation of cyclin D1 at Thr-286 promotes the nuclear-to-
cytoplasmic redistribution of cyclin D1 during S phase of the cell cycle, but how …

We describe the crystal structure of a complex between importin-β residues 1–442 (Ib442)
and five FxFG nucleoporin repeats from Nsp1p. Nucleoporin FxFG cores bind on the convex …

Importin α is the nuclear import receptor that recognizes classical monopartite and bipartite
nuclear localization signals (NLSs). The structure of mouse importin α has been determined …

The recent emergence of two highly pathogenic human coronaviruses (CoVs), severe acute
respiratory syndrome CoV and Middle East respiratory syndrome CoV, has ignited a strong …