Protein engineering with lightweight graph denoising neural networks

B Zhou, L Zheng, B Wu, Y Tan, O Lv, K Yi… - Journal of Chemical …, 2024 - ACS Publications
Protein engineering faces challenges in finding optimal mutants from a massive pool of
candidate mutants. In this study, we introduce a deep-learning-based data-efficient fitness …

ProSST: Protein Language Modeling with Quantized Structure and Disentangled Attention

M Li, Y Tan, X Ma, B Zhong, H Yu, Z Zhou, W Ouyang… - bioRxiv, 2024 - biorxiv.org
Protein language models have exhibited remarkable representational capabilities in various
downstream tasks, notably in the prediction of protein functions. Despite their success, these …