The emerging mechanisms and functions of microautophagy
Abstract 'Autophagy'refers to an evolutionarily conserved process through which cellular
contents, such as damaged organelles and protein aggregates, are delivered to lysosomes …
contents, such as damaged organelles and protein aggregates, are delivered to lysosomes …
[HTML][HTML] The different autophagy degradation pathways and neurodegeneration
The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …
Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques
Autophagy is markedly impaired in Alzheimer's disease (AD). Here we reveal unique
autophagy dysregulation within neurons in five AD mouse models in vivo and identify its …
autophagy dysregulation within neurons in five AD mouse models in vivo and identify its …
The coming of age of chaperone-mediated autophagy
Chaperone-mediated autophagy (CMA) was the first studied process that indicated that
degradation of intracellular components by the lysosome can be selective—a concept that is …
degradation of intracellular components by the lysosome can be selective—a concept that is …
Autophagy and disease: unanswered questions
Y Yang, DJ Klionsky - Cell Death & Differentiation, 2020 - nature.com
Autophagy is a process in which intracellular components and dysfunctional organelles are
delivered to the lysosome for degradation and recycling. Autophagy has various …
delivered to the lysosome for degradation and recycling. Autophagy has various …
[HTML][HTML] Autophagy in Alzheimer's disease pathogenesis: Therapeutic potential and future perspectives
Alzheimer's disease (AD) is a complex neurodegenerative disease in the elderly and the
most common cause of human dementia. AD is characterized by accumulation of abnormal …
most common cause of human dementia. AD is characterized by accumulation of abnormal …
Autophagy and Alzheimer's disease
Q Li, Y Liu, M Sun - Cellular and molecular neurobiology, 2017 - Springer
Autophagy is an essential degradation pathway in clearing abnormal protein aggregates in
mammalian cells and is responsible for protein homeostasis and neuronal health. Several …
mammalian cells and is responsible for protein homeostasis and neuronal health. Several …
Chaperone-mediated autophagy in neurodegenerative diseases: molecular mechanisms and pharmacological opportunities
YT Wang, JH Lu - Cells, 2022 - mdpi.com
Chaperone-mediated autophagy (CMA) is a protein degradation mechanism through
lysosomes. By targeting the KFERQ motif of the substrate, CMA is responsible for the …
lysosomes. By targeting the KFERQ motif of the substrate, CMA is responsible for the …
Therapeutic targeting of BAG3: considering its complexity in cancer and heart disease
Bcl2-associated athanogene-3 (BAG3) is expressed ubiquitously in humans, but its levels
are highest in the heart, the skeletal muscle, and the central nervous system; it is also …
are highest in the heart, the skeletal muscle, and the central nervous system; it is also …
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain
A population of more than six million people worldwide at high risk of Alzheimer's disease
(AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom …
(AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom …