Increasing recognition of the role of B cells in the adaptive immune response makes B cells
an important therapeutic target in autoimmunity. Numerous current and developmental …

Tuberculosis (TB) is an airborne infectious disease that kills almost two million individuals
every year. Multidrug‐resistant (MDR) TB is caused by strains of Mycobacterium …

Background B cells can be enriched within meningeal immune-cell aggregates of multiple
sclerosis (MS) patients, adjacent to subpial cortical demyelinating lesions now recognized …

Multiple sclerosis (MS) is an autoimmune disease of unknown cause, in which chronic
inflammation drives multifocal demyelination of axons in both white and gray matter in the …

Several clinical trials have demonstrated the efficacy of lytic therapies targeting B cells in the
treatment of relapsing multiple sclerosis (MS). More modest efficacy has been noted in the …

Multiple sclerosis (MS) is an immune-mediated and neurodegenerative disorder that results
in inflammation and demyelination of the central nervous system (CNS). MS symptoms …

Introduction: Multiple Sclerosis (MS) is the most common immune-mediated chronic
neurodegenerative disease of the central nervous system (CNS) affecting young people …

Multiple sclerosis (MS), a debilitating autoimmune inflammatory disease that affects the
brain and spinal cord, causes demyelination of neurons, axonal damage, and …

A majority of current therapies for autoimmune diseases are general immunosuppressants,
which can compromise patient response to opportunistic infection and lead to adverse …

Multiple sclerosis (MS) is a multifactorial disease in which both genetic and environmental
factors and their interactions underlie causation. The current evidence base supports a …