The ability of chitosan (CTS) to promote mucoadhesion, trigger positive/negative surface
interactions, and open tight junctions has inspired researchers to coat lipid-based and …

The intrinsic property of cell-penetrating peptides (CPPs) to deliver therapeutic molecules
(nucleic acids, drugs, imaging agents) to cells and tissues in a nontoxic manner has …

While the peptide and protein therapeutic market has developed significantly in the past
decades, delivery has limited their use. Although oral delivery is preferred, most are …

Oral delivery of peptide and protein drugs faces immense challenge partially due to the
gastrointestinal (GI) environment. In spite of considerable efforts by industrial and academic …

The hydrophilic nature of peptides and proteins renders them impermeable to cell
membranes. Thus, in order to successfully deliver peptide and protein-based therapeutics …

Nanoparticles (NPs) have demonstrated great potential for the oral delivery of protein drugs
that have very limited oral bioavailability. Orally administered NPs could be absorbed by the …

Protein and peptide drugs are predominantly administered by injection to achieve high
bioavailability, but this greatly compromises patient compliance. Oral and transdermal drug …

The oral drug administration was convenient and comfortable route for patients.
Nevertheless, the oral uptake efficiency of many therapeutic agents was limited by …

Unique characteristics, such as nontoxicity and rapid cellular internalization, allow the cell-
penetrating peptides (CPPs) to transport hydrophilic macromolecules into cells, thus …

Mesoporous silica nanoparticles functionalized with peptides are developed for sequential
drug delivery. The RGD peptide is used for vasculature/cell membrane targeting and the …