Detection and analysis of chiral molecules as disease biomarkers

Y Liu, Z Wu, DW Armstrong, H Wolosker… - Nature Reviews …, 2023 - nature.com
The chirality of small metabolic molecules is important in controlling physiological processes
and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules …

Promising application of D-amino acids toward clinical therapy

Y Shi, Z Hussain, Y Zhao - International journal of molecular sciences, 2022 - mdpi.com
The versatile roles of D-amino acids (D-AAs) in foods, diseases, and organisms, etc., have
been widely reported. They have been regarded, not only as biomarkers of diseases but …

A D-cysteine desulfhydrase, SlDCD2, participates in tomato fruit ripening by modulating ROS homoeostasis and ethylene biosynthesis

YQ Zhao, KD Hu, GF Yao, SY Wang… - Horticulture …, 2023 - academic.oup.com
Hydrogen sulfide (H2S) is involved in multiple processes during plant growth and
development. D-cysteine desulfhydrase (DCD) can produce H2S with D-cysteine as the …

d-Amino acids: new clinical pathways for brain diseases

IN de Oliveira Souza, R Roychaudhuri… - Trends in Molecular …, 2023 - cell.com
Free d-amino acids (d-AAs) are emerging as a novel and important class of signaling
molecules in many organs, including the brain and endocrine systems. There has been …

d‐Amino acids in biological systems

S Du, M Wey, DW Armstrong - Chirality, 2023 - Wiley Online Library
Investigations on the occurrence and biochemical roles of free D‐amino acids and D‐amino
acid‐containing peptides and proteins in living systems have increased in frequency and …

H2S-Generating Cytosolic L-Cysteine Desulfhydrase and Mitochondrial D-Cysteine Desulfhydrase from Sweet Pepper (Capsicum annuum L.) Are Regulated During …

MA Muñoz-Vargas, J López-Jaramillo… - Antioxidants & Redox …, 2023 - liebertpub.com
Aims: Pepper fruit is a horticultural product worldwide consumed that has great nutritional
and economic relevance. Besides the phenotypical changes that undergo pepper fruit …

Hydrogen sulfide and polysulfides induce GABA/glutamate/d-serine release, facilitate hippocampal LTP, and regulate behavioral hyperactivity

H Furuie, Y Kimura, T Akaishi, M Yamada… - Scientific reports, 2023 - nature.com
Hydrogen sulfide (H2S) and polysulfides (H2Sn, n≥ 2) are signaling molecules produced
by 3-mercaptopyruvate sulfurtransferase (3MST) that play various physiological roles …

L-cysteine methyl ester overcomes the deleterious effects of morphine on ventilatory parameters and arterial blood-gas chemistry in unanesthetized rats

PM Getsy, SM Baby, WJ May, JN Bates… - Frontiers in …, 2022 - frontiersin.org
We are developing a series of thiolesters that produce an immediate and sustained reversal
of the deleterious effects of opioids, such as morphine and fentanyl, on ventilation without …

[HTML][HTML] The ventilatory depressant actions but not the antinociceptive effects of morphine are blunted in rats receiving intravenous infusion of L-cysteine ethyl ester

THJ Lewis, WJ May, AP Young, JN Bates… - Biomedicine & …, 2022 - Elsevier
This study demonstrates that intravenous infusion of the cell-penetrant thiol ester, L-cysteine
ethyl ester (L-CYSee), to adult male Sprague-Dawley rats elicited (a) minor alterations in …

Hydrogen Sulfide (H2S)/Polysulfides (H2Sn) Signalling and TRPA1 Channels Modification on Sulfur Metabolism

H Kimura - Biomolecules, 2024 - mdpi.com
Hydrogen sulfide (H2S) and polysulfides (H2Sn, n≥ 2) produced by enzymes play a role as
signalling molecules regulating neurotransmission, vascular tone, cytoprotection …