Antifungal Resistance in Cryptococcal Infections

MSC Melhem, DP Leite Júnior, JPF Takahashi… - Pathogens, 2024 - mdpi.com
Antifungal therapy, especially with the azoles, could promote the incidence of less
susceptible isolates of Cryptococcus neoformans and C. gattii species complexes (SC) …

Exposure of Cryptococcus neoformans to Seven Commonly Used Agricultural Azole Fungicides Induces Resistance to Fluconazole as Well as Cross-Resistance to …

P Drakulovski, D Krasteva, V Bellet, S Randazzo… - Pathogens, 2023 - mdpi.com
Background: Cross-resistance to medical azoles by exposure to azole pesticides is well
documented for Aspergillus family fungi but is poorly evaluated for other environmental …

Deciphering antifungal and antibiofilm mechanisms of isobavachalcone against Cryptococcus neoformans through RNA-seq and functional analyses

W Qian, J Lu, C Gao, Q Liu, Y Li, Q Zeng, J Zhang… - Microbial Cell …, 2024 - Springer
Cryptococcus neoformans has been designated as critical fungal pathogens by the World
Health Organization, mainly due to limited treatment options and the prevalence of …

Fluconazole Resistance and Virulence in In Vitro Induced-Fluconazole Resistant Strains and in Clinical Fluconazole Resistant Strain of Cryptococcus deuterogattii

S Bertout, L Laroche, F Roger, D Krasteva… - Pathogens, 2023 - mdpi.com
Neuromeningeal cryptococcosis is a life-threatening infection of the central nervous system,
caused by encapsulated yeast belonging to the Cryptococcus neoformans and …

Achieving Resilience in Aging: How Mitochondrial Modulation Drives Age-associated Fluconazole Tolerance in Cryptococcus neoformans

K Yoo, NK Oliveira, S Bhattacharya, BC Fries - bioRxiv, 2024 - biorxiv.org
Cryptococcus neoformans (Cn) is an opportunistic fungal microorganism that causes life-
threatening meningoencephalitis. During the infection, the microbial population is …

Lack of an atypical PDR transporter generates an immunogenic Cryptococcus neoformans strain that drives a dysregulated and lethal immune response in murine …

CJ Winski, PV Stuckey, AM Marrufo, RL Ross, G Agyei… - bioRxiv, 2024 - biorxiv.org
Cryptococcus neoformans is an opportunistic fungal pathogen responsible for> 150,000
deaths every year with a mortality rate as high as 81%. This high medical burden is due, in …

Transcriptomics uncovers key genes for photodynamic killing on Trichosporon asahii biofilms

W Luo, G Wang, H Chang, G Liu, H Zhu, H Li - 2023 - researchsquare.com
The escalating threat of antifungal resistance stemming from Trichosporon asahii (T. asahii)
biofilms necessitates the pursuit of innovative therapeutic strategies. Among these …