The amyloid-β oligomer hypothesis: beginning of the third decade
The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
Amyloid β protein and Alzheimer's disease: When computer simulations complement experimental studies
J Nasica-Labouze, PH Nguyen, F Sterpone… - Chemical …, 2015 - ACS Publications
Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia
JD Marks, VE Ayuso, Y Carlomagno, M Yue… - Science translational …, 2024 - science.org
Genetic variation at the transmembrane protein 106B gene (TMEM106B) has been linked to
risk of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) through an …
risk of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) through an …
Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease
K Rajasekhar, M Chakrabarti… - Chemical …, 2015 - pubs.rsc.org
Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …
Visualizing transient dark states by NMR spectroscopy
Myriad biological processes proceed through states that defy characterization by
conventional atomic-resolution structural biological methods. The invisibility of these …
conventional atomic-resolution structural biological methods. The invisibility of these …
Application of NMR to studies of intrinsically disordered proteins
EB Gibbs, EC Cook, SA Showalter - Archives of biochemistry and …, 2017 - Elsevier
The prevalence of intrinsically disordered protein regions, particularly in eukaryotic proteins,
and their clear functional advantages for signaling and gene regulation have created an …
and their clear functional advantages for signaling and gene regulation have created an …
Reversible kinetic trapping of FUS biomolecular condensates
S Chatterjee, Y Kan, M Brzezinski, K Koynov… - Advanced …, 2022 - Wiley Online Library
Formation of membrane‐less organelles by self‐assembly of disordered proteins can be
triggered by external stimuli such as pH, salt, or temperature. These organelles, called …
triggered by external stimuli such as pH, salt, or temperature. These organelles, called …
Molecular tools to detect alloforms of Aβ and Tau: Implications for multiplexing and multimodal diagnosis of Alzheimer's disease
The advancements in the field of imaging and diagnostics have been benefitted by the
concurrent expansion of molecular probes space to monitor the diverse biological targets …
concurrent expansion of molecular probes space to monitor the diverse biological targets …
NMR methods for exploring 'dark'states in ligand binding and protein-protein interactions
A survey, primarily based on work in the authors' laboratory during the last 10 years, is
provided of recent developments in NMR studies of exchange processes involving protein …
provided of recent developments in NMR studies of exchange processes involving protein …
Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice
A Ruiz-Riquelme, A Mao, MM Barghash… - Acta neuropathologica …, 2021 - Springer
When injected into genetically modified mice, aggregates of the amyloid-β (Aβ) peptide from
the brains of Alzheimer's disease (AD) patients or transgenic AD mouse models seed …
the brains of Alzheimer's disease (AD) patients or transgenic AD mouse models seed …