Mechanisms of melanocyte death in vitiligo

J Chen, S Li, C Li - Medicinal Research Reviews, 2021 - Wiley Online Library
Vitiligo is an autoimmune depigment disease results from extensive melanocytes
destruction. The destruction of melanocyte is thought to be of multifactorial causation …

Vitiligo treatments: review of current therapeutic modalities and JAK inhibitors

KN Cunningham, D Rosmarin - American journal of clinical dermatology, 2023 - Springer
Vitiligo is a chronic autoimmune disease characterized by loss of pigment of the skin,
affecting 0.5–2% of the population worldwide. It can have a significant impact on patients' …

Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the International Vitiligo Task Force Part 1: towards a new …

N van Geel, R Speeckaert, A Taïeb… - Journal of the …, 2023 - Wiley Online Library
Background The treatment of vitiligo can be challenging and depends on several factors
such as the subtype, disease activity, vitiligo extent, and treatment goals. Vitiligo usually …

[HTML][HTML] Efficacy and safety of oral ritlecitinib for the treatment of active nonsegmental vitiligo: a randomized phase 2b clinical trial

K Ezzedine, E Peeva, Y Yamaguchi, LA Cox… - Journal of the American …, 2023 - Elsevier
Background Vitiligo is a chronic autoimmune disorder characterized by depigmented
patches of the skin. Objective To evaluate the efficacy and safety of ritlecitinib, an oral JAK3 …

[HTML][HTML] Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis

X Liu, G Yang, M Luo, Q Lan, X Shi, H Deng, N Wang… - PLoS …, 2021 - journals.plos.org
Background Vitamin E has long been linked to skin health, including all of its possible
functions in cosmetic products, to its roles in membrane integrity and even the aging …

Premature cell senescence in human skin: Dual face in chronic acquired pigmentary disorders

B Bellei, M Picardo - Ageing Research Reviews, 2020 - Elsevier
Although senescence was originally described as an in vitro acquired cellular characteristic,
it was recently recognized that senescence is physiologically and pathologically involved in …

Emerging drugs for the treatment of vitiligo

P Karagaiah, Y Valle, J Sigova, N Zerbinati… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction: Vitiligo is a relatively common autoimmune depigmenting disorder of the skin.
There has been a great advance in understanding the pathological basis, which has led to …

Increased Serum Levels of IFN‐γ, IL‐1β, and IL‐6 in Patients with Alopecia Areata and Nonsegmental Vitiligo

K Tomaszewska, M Kozłowska… - Oxidative Medicine …, 2020 - Wiley Online Library
Alopecia areata (AA) and vitiligo are both common skin diseases of autoimmune origin. Both
alopecia areata and vitiligo have shown to be affected by oxidative stress. The present work …

MC1R Peptide Agonist Self-Assembles into a Hydrogel That Promotes Skin Pigmentation for Treating Vitiligo

C Zhu, T Li, Z Wang, Z Li, J Wei, H Han, D Yuan… - ACS …, 2023 - ACS Publications
Vitiligo, a common skin disease that seriously affects 0.5–2.0% of the worldwide population,
lacks approved therapeutics due to a wide range of adverse side effects. As a key regulator …

Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta‐analysis

R Speeckaert, J Dugardin, J Lambert… - Journal of the …, 2018 - Wiley Online Library
Background The pathogenesis of vitiligo remains a topic of extensive debate. This is partly
due to the moderate efficacy of current treatments. The role of the oxidative stress pathway in …