Hypoxia induced changes of exosome cargo and subsequent biological effects

H Jiang, H Zhao, M Zhang, Y He, X Li, Y Xu… - Frontiers in …, 2022 - frontiersin.org
Exosomes are small extracellular vesicles that are secreted by almost all types of cells and
exist in almost all extracellular spaces. As an important mediator of intercellular …

Obstructive nephropathy and molecular pathophysiology of renal interstitial fibrosis

R Nørregaard, HAM Mutsaers… - Physiological …, 2023 - journals.physiology.org
The kidneys play a key role in maintaining total body homeostasis. The complexity of this
task is reflected in the unique architecture of the organ. Ureteral obstruction greatly affects …

Extracellular vesicles: emerging roles, biomarkers and therapeutic strategies in fibrotic diseases

J Zhu, S Wang, D Yang, W Xu, H Qian - Journal of Nanobiotechnology, 2023 - Springer
Extracellular vesicles (EVs), a cluster of cell-secreted lipid bilayer nanoscale particles,
universally exist in body fluids, as well as cell and tissue culture supernatants. Over the past …

Circulating non-coding RNAs in chronic kidney disease and its complications

AJ van Zonneveld, Q Zhao, JI Rotmans… - Nature Reviews …, 2023 - nature.com
Post-transcriptional regulation by non-coding RNAs (ncRNAs) can modulate the expression
of genes involved in kidney physiology and disease. A large variety of ncRNA species exist …

Biomodified Extracellular Vesicles Remodel the Intestinal Microenvironment to Overcome Radiation Enteritis

H Li, S Zhao, M Jiang, T Zhu, J Liu, G Feng, L Lu… - ACS …, 2023 - ACS Publications
Ionizing radiation (IR) is associated with the occurrence of enteritis, and protecting the whole
intestine from radiation-induced gut injury remains an unmet clinical need. Circulating …

Exploring the role of urinary extracellular vesicles in kidney physiology, aging, and disease progression

C Grange, A Dalmasso, JJ Cortez… - … of Physiology-Cell …, 2023 - journals.physiology.org
Extracellular vesicles (EVs), membranous vesicles present in all body fluids, are considered
important messengers, carrying their information over long distance and modulating the …

[HTML][HTML] An update on renal fibrosis: from mechanisms to therapeutic strategies with a focus on extracellular vesicles

C Wang, SW Li, X Zhong, BC Liu… - Kidney Research and …, 2023 - ncbi.nlm.nih.gov
The increasing prevalence of chronic kidney disease (CKD) is a major global public health
concern. Despite the complicated pathogenesis of CKD, renal fibrosis represents the most …

An emerging frontier in intercellular communication: extracellular vesicles in regeneration

PN Avalos, DJ Forsthoefel - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Regeneration requires cellular proliferation, differentiation, and other processes that are
regulated by secreted cues originating from cells in the local environment. Recent studies …

Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis

C Xie, L Zhong, H Feng, R Wang, Y Shi, Y Lv… - International Journal of …, 2024 - nature.com
Oral submucous fibrosis (OSF) is a chronic and inflammatory mucosal disease caused by
betel quid chewing, which belongs to oral potentially malignant disorders. Abnormal …

Exosomal miR-103a-3p from Crohn's creeping fat-derived adipose-derived stem cells contributes to intestinal fibrosis by targeting TGFBR3 and activating fibroblasts

W Qian, Y Xu, W Wen, L Huang, Z Guo… - Journal of Crohn's …, 2023 - academic.oup.com
Abstract Background and Aims Mesenteric adipose tissue hypertrophy is a hallmark of
Crohn's disease [CD], and creeping fat [CF] is unique to CD. Adipose-derived stem cells …