Resistance to tyrosine kinase inhibitors in chronic myeloid leukemia—from molecular mechanisms to clinical relevance
Simple Summary Chronic myeloid leukemia (CML) is a myeloproliferative neoplasia
associated with a molecular alteration, the fusion gene BCR-ABL1, that encodes the tyrosine …
associated with a molecular alteration, the fusion gene BCR-ABL1, that encodes the tyrosine …
Third-line therapy for chronic myeloid leukemia: current status and future directions
J Cortes, F Lang - Journal of Hematology & Oncology, 2021 - Springer
Chronic myeloid leukemia (CML) is driven by the BCR-ABL1 fusion protein, formed by a
translocation between chromosomes 9 and 22 that creates the Philadelphia chromosome …
translocation between chromosomes 9 and 22 that creates the Philadelphia chromosome …
Iron: The cancer connection
SV Torti, FM Torti - Molecular aspects of medicine, 2020 - Elsevier
Iron plays an essential role in normal biological processes: The generation of cellular
energy, oxygen transport, DNA synthesis and repair are all processes that require iron …
energy, oxygen transport, DNA synthesis and repair are all processes that require iron …
[HTML][HTML] Natural killer cells in myeloid malignancies: immune surveillance, NK cell dysfunction, and pharmacological opportunities to bolster the endogenous NK cells
M Carlsten, M Järås - Frontiers in immunology, 2019 - frontiersin.org
Natural killer (NK) cells are large granular lymphocytes involved in our defense against
certain virus-infected and malignant cells. In contrast to T cells, NK cells elicit rapid anti …
certain virus-infected and malignant cells. In contrast to T cells, NK cells elicit rapid anti …
Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response
Virus-infected cells and cancers share metabolic commonalities that stem from their
insatiable need to replicate while evading the host immune system. These similarities …
insatiable need to replicate while evading the host immune system. These similarities …
Polycythemia vera and essential thrombocythemia: 2021 update on diagnosis, risk‐stratification and management
Disease overview Polycythemia vera (PV) and essential thrombocythemia (ET) are
myeloproliferative neoplasms (MPN) respectively characterized by clonal erythrocytosis and …
myeloproliferative neoplasms (MPN) respectively characterized by clonal erythrocytosis and …
The role of fibroblast growth factor receptor (FGFR) protein-tyrosine kinase inhibitors in the treatment of cancers including those of the urinary bladder
R Roskoski Jr - Pharmacological research, 2020 - Elsevier
The human fibroblast growth factor family consists of 22 factors and five transmembrane
receptors. Of the 22 factors, eighteen are secreted while four of them function exclusively …
receptors. Of the 22 factors, eighteen are secreted while four of them function exclusively …
Cardiovascular toxicity of tyrosine kinase inhibitors used in chronic myeloid leukemia: an analysis of the FDA adverse event reporting system database (FAERS)
Tyrosine kinase inhibitors (TKIs), the treatment of choice for chronic myeloid leukemia
(CML), can be associated to cardiovascular (CV) adverse events (AEs). A case/non-case …
(CML), can be associated to cardiovascular (CV) adverse events (AEs). A case/non-case …
Prospective assessment of NGS-detectable mutations in CML patients with nonoptimal response: the NEXT-in-CML study
S Soverini, L Bavaro, C De Benedittis… - Blood, The Journal …, 2020 - ashpublications.org
In chronic myeloid leukemia (CML) patients, tyrosine kinase inhibitors (TKIs) may select for
drug-resistant BCR-ABL1 kinase domain (KD) mutants. Although Sanger sequencing (SS) is …
drug-resistant BCR-ABL1 kinase domain (KD) mutants. Although Sanger sequencing (SS) is …
Bosutinib for pretreated patients with chronic phase chronic myeloid leukemia: primary results of the phase 4 BYOND study
A Hochhaus, C Gambacorti-Passerini, C Abboud… - Leukemia, 2020 - nature.com
Bosutinib is approved for newly diagnosed Philadelphia chromosome-positive (Ph+) chronic
phase (CP) chronic myeloid leukemia (CML) and for Ph+ CP, accelerated (AP), or blast (BP) …
phase (CP) chronic myeloid leukemia (CML) and for Ph+ CP, accelerated (AP), or blast (BP) …