[HTML][HTML] The neuroimmune axis of Alzheimer's disease

M Jorfi, A Maaser-Hecker, RE Tanzi - Genome Medicine, 2023 - Springer
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …

Modulators of microglial activation and polarization after intracerebral haemorrhage

X Lan, X Han, Q Li, QW Yang, J Wang - Nature Reviews Neurology, 2017 - nature.com
Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks
effective treatment. Microglia are among the first non-neuronal cells on the scene during the …

[HTML][HTML] Neuroinflammation after intracerebral hemorrhage and potential therapeutic targets

C Tschoe, CD Bushnell, PW Duncan… - Journal of …, 2020 - ncbi.nlm.nih.gov
Spontaneous intracerebral hemorrhage (ICH) is a catastrophic illness causing significant
morbidity and mortality. Despite advances in surgical technique addressing primary brain …

Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage

H Zhu, Z Wang, J Yu, X Yang, F He, Z Liu, F Che… - Progress in …, 2019 - Elsevier
Intracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has
high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic …

[HTML][HTML] Microglia and monocytes/macrophages polarization reveal novel therapeutic mechanism against stroke

M Kanazawa, I Ninomiya, M Hatakeyama… - International journal of …, 2017 - mdpi.com
Stroke is a leading cause of morbidity and mortality worldwide, and consists of two types,
ischemic and hemorrhagic. Currently, there is no effective treatment to increase the survival …

[HTML][HTML] SIRT1 Promotes M2 Microglia Polarization via Reducing ROS-Mediated NLRP3 Inflammasome Signaling After Subarachnoid Hemorrhage

DY Xia, JL Yuan, XC Jiang, M Qi, NS Lai… - Frontiers in …, 2021 - frontiersin.org
Mounting evidence has suggested that modulating microglia polarization from pro-
inflammatory M1 phenotype to anti-inflammatory M2 state might be a potential therapeutic …

IL-4 switches microglia/macrophage M1/M2 polarization and alleviates neurological damage by modulating the JAK1/STAT6 pathway following ICH

Y He, Y Gao, Q Zhang, G Zhou, F Cao, S Yao - Neuroscience, 2020 - Elsevier
Inflammatory damage following ICH is often attributed to microglia/macrophage activation. In
many diseases, IL-4 has been proven to switch microglia/macrophages from the pro …

[HTML][HTML] Oxidative stress following intracerebral hemorrhage: from molecular mechanisms to therapeutic targets

Y Zhang, S Khan, Y Liu, G Wu, VW Yong… - Frontiers in …, 2022 - frontiersin.org
Intracerebral hemorrhage (ICH) is a highly fatal disease with mortality rate of approximately
50%. Oxidative stress (OS) is a prominent cause of brain injury in ICH. Important sources of …

[HTML][HTML] Behavioral assessment of sensory, motor, emotion, and cognition in rodent models of intracerebral hemorrhage

X Shi, H Bai, J Wang, J Wang, L Huang, M He… - Frontiers in …, 2021 - frontiersin.org
Intracerebral hemorrhage (ICH) is the second most common type of stroke and has one of
the highest fatality rates of any disease. There are many clinical signs and symptoms after …

The role of the immune system in Alzheimer's disease

KM Wu, YR Zhang, YY Huang, Q Dong, L Tan… - Ageing research …, 2021 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disorder where the
accumulation of amyloid plaques and the formation of tau tangles are the prominent …