Age is the main risk factor for the prevalent diseases of developed countries: cancer,
cardiovascular disease and neurodegeneration. The ageing process is deleterious for …

The heart must continuously pump blood to supply the body with oxygen and nutrients. To
maintain the high energy consumption required by this role, the heart is equipped with …

Rationale: Cardiac aging is an important contributing factor for heart failure, which affects a
large population but remains poorly understood. Objective: The purpose of this study is to …

Here we show that Mst1, a proapoptotic kinase, impairs protein quality control mechanisms
in the heart through inhibition of autophagy. Stress-induced activation of Mst1 in …

Aging is a complex, multifaceted process that induces a myriad of physiological changes
over an extended period of time. Aging is accompanied by major biochemical and …

MicroRNAs (miRNAs) are short, non-coding RNAs that post-transcriptionally repress
translation or induce mRNA degradation of target transcripts through sequence-specific …

In mammals, aging is associated with accumulation of senescent cells. Stresses such as
telomere shortening and reactive oxygen species induce “cellular senescence”, which is …

Cardiac troponin testing is commonly performed in patients with heart failure (HF). Despite
being strongly linked to spontaneous (Type I) acute myocardial infarction (MI)—a common …

Aging is associated with significant changes in both cardiac and vascular structure and
function that lower the threshold for clinical signs and symptoms, making older people more …

Atherosclerosis and its sequelae, such as myocardial infarction and stroke, are the leading
cause of death worldwide. Vascular endothelial cells (EC) play a critical role in vascular …