In addition to conventional protein secretion, dependent on the specific cleavage of signal
sequences, proteins are secreted by other processes, all together called unconventional …

Highlights•Cells, organs, and the whole body are continuously exposed to various types of
stressors.•Hormesis is an adaptive phenomenon characterized by low-dose stimulation and …

E3 ligase recruitment of proteins containing terminal destabilizing motifs (degrons) is
emerging as a major form of regulation. How those E3s discriminate bona fide substrates …

Cells contain numerous abundant molecular machines assembled from multiple subunits.
Imbalances in subunit production and failed assembly generate orphan subunits that are …

All eukaryotes require intricate protein networks to translate developmental signals into
accurate cell fate decisions. Mutations that disturb interactions between network …

Abstract Assembly Quality Control (AQC) E3 ubiquitin ligases target incomplete or
incorrectly assembled protein complexes for degradation. The CUL4‐RBX1‐DDB1‐DCAF12 …

The eukaryotic proteome undergoes constant surveillance by quality control systems that
either sequester, refold, or eliminate aberrant proteins by ubiquitin-dependent mechanisms …

Endoplasmic reticulum (ER) luminal Ca2+ is vital for the function of the ER and regulates
many cellular processes. Calreticulin is a highly conserved, ER‐resident Ca2+ binding …

Synthetic lethality provides an attractive strategy for developing targeted cancer therapies.
For example, cancer cells with high levels of microsatellite instability (MSI-H) are dependent …

Full understanding of proteostasis and energy utilization in cells will require knowledge of
the fraction of cell proteins being degraded with different half-lives and their rates of …