Oxidative stress is linked with many pathologies ranging from cancer to neurodegenerative
disorders and antioxidants have presumably therapeutic value in such diseases. In this …

The acetylation of histone and non-histone proteins controls a great deal of cellular
functions, thereby affecting the entire organism, including the brain. Acetylation …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal motor neuron disease.
Diagnosis typically occurs in the fifth decade of life and the disease progresses rapidly …

We all know that age-related neurodegenerative diseases affect aging individuals. So why
does basic research continue to make use of the immature nervous system or mutants that …

Objective To develop and implement an evidence based framework to select, from drugs
already licenced, candidate oral neuroprotective drugs to be tested in secondary …

Pathogenesis of familial amyotrophic lateral sclerosis (ALS) linked to expansion of the
chromosome 9 open reading frame 72 (C9orf72) hexanucleotide repeat that impairs …

There is a desperate need for targeted therapeutic interventions that slow the progression of
amyotrophic lateral sclerosis (ALS). ALS is a disorder with heterogeneous onset, which then …

In the spinal cord neuronal activity is controlled by the balance between excitatory and
inhibitory neurotransmission, mediated mainly by the neurotransmitters glutamate and …

Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder
characterized by progressive muscle weakness, paralysis and death. There is no effective …

Neurodegenerative diseases are characterized by the progressive loss of neurons and glial
cells in the central nervous system correlated to their symptoms. Among these …