Axon degeneration has been implicated as a pathological process in several
neurodegenerative diseases and acquired forms of neural injury. We have previously shown …

We report the methodology for the chronic delivery of an excitotoxin to the mouse spinal cord
via surgically implanted osmotic mini-pumps. Previous studies have investigated the effect of …

The study of the genetics of drug responses has a long history but has provided only a few
examples of gene variants that are relevant clinically. Here, we discuss the current state of …

The introduction of fluorine in drug-like compounds is now a well-accepted and very efficient
strategy in drug discovery, encouraged by the extensive synthetic methodologies available …

BACKGROUND: Eye-tracking communication devices and brain-computer interfaces are the
two resources available to help people with advanced amyotrophic lateral sclerosis (ALS) …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder typified by a
massive loss of motor neurons with few therapeutic options. The exact cause of neuronal …

Abstract Neurodegenerative disorders (NDDs)(Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease) represent a major …

Purpose: This study assessed (a) the impact of a technology-aided programme on the
leisure and communication engagement of persons with advanced amyotrophic lateral …

Disease modifying treatment of amyotrophic lateral sclerosis All topics are updated as new
evidence becomes availa Page 1 05/02/2018 Disease modifying treatment of amyotrophic …

This thesis investigated the effects of pharmacological and non-pharmacological therapeutic
approaches on skeletal muscle health and disease progression in a novel mouse model …