Exosomes─ nature's lipid nanoparticles, a rising star in drug delivery and diagnostics
Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …
Messenger RNA-based therapeutics and vaccines: what's beyond COVID-19?
With the rapid success in the development of mRNA vaccines against COVID-19 and with a
number of mRNA-based drugs ahead in the pipelines, mRNA has catapulted to the forefront …
number of mRNA-based drugs ahead in the pipelines, mRNA has catapulted to the forefront …
The chromatin-associated RNAs in gene regulation and cancer
J Tang, X Wang, D Xiao, S Liu, Y Tao - Molecular Cancer, 2023 - Springer
Eukaryotic genomes are prevalently transcribed into many types of RNAs that translate into
proteins or execute gene regulatory functions. Many RNAs associate with chromatin directly …
proteins or execute gene regulatory functions. Many RNAs associate with chromatin directly …
β-Glucan and fatty acid based mucoadhesive carrier for gastrointestinal tract specific local and sustained drug delivery
The oral route is considered the most convenient route of drug administration for both
systemic and local delivery. Besides stability and transportation, another unmet but …
systemic and local delivery. Besides stability and transportation, another unmet but …
Biomaterial‐based gene therapy
Y Yu, Y Gao, L He, B Fang, W Ge, P Yang, Y Ju… - MedComm, 2023 - Wiley Online Library
Gene therapy, a medical approach that involves the correction or replacement of defective
and abnormal genes, plays an essential role in the treatment of complex and refractory …
and abnormal genes, plays an essential role in the treatment of complex and refractory …
Enhancing the effectiveness of oligonucleotide therapeutics using cell-penetrating peptide conjugation, chemical modification, and carrier-based delivery strategies
Oligonucleotide-based therapies are a promising approach for treating a wide range of hard-
to-treat diseases, particularly genetic and rare diseases. These therapies involve the use of …
to-treat diseases, particularly genetic and rare diseases. These therapies involve the use of …
miRNAs: the road from bench to bedside
G Iacomino - Genes, 2023 - mdpi.com
miRNAs are small noncoding RNAs that control gene expression at the posttranscriptional
level. It has been recognised that miRNA dysregulation reflects the state and function of cells …
level. It has been recognised that miRNA dysregulation reflects the state and function of cells …
Nanomedicine as potential cancer therapy via targeting dysregulated transcription factors
Cancer as a disease possess quite complicated pathophysiological implications and is
among the prominent causes of morbidity and mortality on global scales. Anti-cancer …
among the prominent causes of morbidity and mortality on global scales. Anti-cancer …
miRNAs as Modern Biomarkers in Asthma Therapy
N Kierbiedź-Guzik, B Sozańska - International journal of molecular …, 2023 - mdpi.com
Asthma is a chronic inflammatory disease of the airways characterized by shortness of
breath, chest tightness, coughing, and wheezing. For several decades (approximately 30 …
breath, chest tightness, coughing, and wheezing. For several decades (approximately 30 …
RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy
WW Liu, SQ Zheng, T Li, YF Fei, C Wang… - … and Targeted Therapy, 2024 - nature.com
Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis
requirements of cells. Relevant studies have been constantly making inroads in our …
requirements of cells. Relevant studies have been constantly making inroads in our …