Hypertension is a major risk factor for heart attack, produce atherosclerosis (hardening of the
arteries), congestive heart failure, stroke, kidney infection, blindness, end-stage renal …

Drug repurposing aims to identify new therapeutic uses for drugs that have already been
approved for other conditions. This approach can save time and resources compared to …

This phase III study assessed the efficacy and safety of sacubitril/valsartan compared with
those of olmesartan in Japanese patients with essential hypertension. Patients (n= 1161 …

Blood pressure lowering by all classes of antihypertensive drugs is accompanied by
significant reductions of stroke and major cardiovascular (CV) events. Drugs acting on the …

Elevated blood pressure (BP) is a major determinant of morbidity and mortality burden
related to cardio‐metabolic risk. Current guidelines indicate that controlling and lowering BP …

Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are drugs
commonly used for the treatment of hypertension. However, studies on their comparative …

Purpose Angiotensin II type 1 receptor blockers (ARBs) have been investigated for their
neuroprotective and intraocular pressure (IOP) lowering effects in treating glaucoma, but the …

Introduction Since sacubitril/valsartan (LCZ696) has neprilysin inhibition and angiotensin
receptor-blocking properties, it is anticipated to have strong antihypertensive effects …

There is a lack of studies comparing the risk of cardio-cerebrovascular disease between
angiotensin receptor blockers (ARBs) of different half-lives. We aimed to compare the risks …

Background: Angiotensin II receptor blockers (ARBs) are widely used for the management of
hypertension in Japan; however, comparative efficacy data within the ARB drug class …