Amentoflavone as an ally in the treatment of cutaneous leishmaniasis: analysis of its antioxidant/prooxidant mechanisms

YS Rizk, S Santos-Pereira, L Gervazoni… - Frontiers in cellular …, 2021 - frontiersin.org
Treatment of leishmaniasis is a challenging subject. Although available, chemotherapy is
limited, presenting toxicity and adverse effects. New drugs with antileishmanial activity are …

An old drug and different ways to treat cutaneous leishmaniasis: intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazil

C Oliveira-Ribeiro, MIF Pimentel… - PLoS Neglected …, 2021 - journals.plos.org
Background Treatment of cutaneous leishmaniasis (CL) remains challenging since the
drugs currently used are quite toxic, thus contributing to lethality unrelated to the disease …

Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit

MC de Oliveira Duque, JJQ Silva, PAO Soares… - Acta tropica, 2019 - Elsevier
Cutaneous leishmaniasis (CL) is not a life-threatening condition. However, its treatment can
cause serious adverse effects and may sometimes lead to death. Recently, safer local …

Intralesional meglumine antimoniate: safe, feasible and effective therapy for cutaneous leishmaniasis in Bolivia

E Rojas Cabrera, A Verduguez-Orellana… - Tropical Medicine and …, 2022 - mdpi.com
The standard of care for cutaneous leishmaniasis includes the intramuscular/intravenous
administration of pentavalent antimonials that are toxic and poorly tolerated. Primary health …

[HTML][HTML] La leishmaniosis cutánea en Costa Rica: prevención, diagnóstico y tratamiento

O Jaramillo-Antillón, A Espinoza-Aguirre… - Acta Médica …, 2018 - scielo.sa.cr
El objetivo de esta investigación fue describir el estado actual de la leishmaniosis en Costa
Rica, profundizar en las diferentes manifestaciones clínicas y en las especies identificadas …

A Randomized, Controlled, Noninferiority, Multicenter Trial of Systemic vs Intralesional Treatment With Meglumine Antimoniate for Cutaneous Leishmaniasis in Brazil

MR Lyra, LFA Oliveira, AO Schubach… - Clinical Infectious …, 2023 - academic.oup.com
Background Meglumine antimoniate (MA) remains the main treatment for cutaneous
leishmaniasis (CL). Uncontrolled studies suggest that intralesional MA (IL-MA) may be …

Successful treatment of cutaneous leishmaniasis with intralesional meglumine antimoniate: A case series

M Arboleda, S Barrantes, LY Úsuga… - Revista da Sociedade …, 2019 - SciELO Brasil
Cutaneous leishmaniasis (CL) is a high-morbidity, vector-borne disease endemic to
Colombia. Unlike conventional systemic antileishmanial therapy, intralesional meglumine …

Genistein and ascorbic acid reduce oxidative stress-derived DNA damage induced by the antileishmanial meglumine antimoniate

LCL de Jesus, REP Soares, VR Moreira… - Antimicrobial agents …, 2018 - Am Soc Microbiol
Meglumine antimoniate (Glucantime) is a pentavalent antimonial used to treat
leishmaniasis, despite its acknowledged toxic effects, such as its ability to cause oxidative …

Intralesional Antimonial Drug Treatment for Leishmania braziliensis Cutaneous Leishmaniasis: The Knowns and the Unknowns

NE Aronson, K Billick - Clinical Infectious Diseases, 2023 - academic.oup.com
(CL) due to Leishmania (L.) Viannia (V.) braziliensis (LVb). The first recommendation
(strong, low certainty evidence) is to use intralesional (IL) pentavalent antimonial drugs …

Successful treatment against American cutaneous leishmaniasis by intralesional infiltration of a generic antimonial compound-lidocaine combination. A follow up …

N Añez, A Rojas, JV Scorza-Dagert, C Morales - Acta tropica, 2018 - Elsevier
One hundred and twenty-two lesions caused by Leishmania braziliensis in 92 patients were
treated using weekly intralesional (IL) infiltrations of a generic pentavalent antimonial …