Cancer is widely perceived as a heterogeneous group of disorders with markedly different
biological properties, which are caused by a series of clonally selected genetic changes in …

Folates, also known as B9 vitamins, serve as donors and acceptors in one-carbon (C1)
transfer reactions. The latter are involved in synthesis of many important biomolecules, such …

Background & Aims: The involvement of the hepatitis B virus X (HBx) protein in epigenetic
modifications during hepatocarcinogenesis has not been previously characterized. The aim …

Background: Head and neck squamous cell carcinoma (HNSCC) is commonly associated
with tobacco and alcohol exposures, although dietary factors, particularly folate, and human …

IGF2 loss of imprinting (LOI) is fairly prevalent and implicated in the pathogenesis of human
cancer and developmental disease; however, the causes of this phenomenon are largely …

During the fifteen years since the bestselling first edition of Folate in Health and Disease
was published, there have been thousands of new research studies related to folate and its …

Inorganic arsenic is a human carcinogen that can target the liver, but its carcinogenic
mechanisms are still unknown. Global DNA hypomethylation occurs during arsenic-induced …

Cadmium is a toxic transition metal of continuing occupational and environmental concern.
As a well-recognized human carcinogen, its carcinogenic mechanisms are still poorly …

It is thought that germ cells and preimplantation embryos during development are most
susceptible to endogenous and exogenous environmental factors because the epigenome …

The methylation status of the CpG island located within the ribosomal RNA (rRNA) promoter
in human hepatocellular carcinomas and pair-matched liver tissues was analyzed by …