Obesity is becoming increasingly prevalent in paediatric populations worldwide. In addition
to increasing prevalence, the severity of obesity is also continuing to rise. Taken together …

Data from clinical trials, retrospective and cross-sectional studies have quantified the
metabolic changes associated with long-term use of antiepileptic drugs (AEDs). AEDs can …

Dietary factors have been implicated in at least four of the ten leading causes of death in the
US (heart disease, cancer, diabetes, and stroke). Nevertheless, physicians frequently …

" This book has been divided into three main sections. Part I deals with global issues that
bear on the assessment and formulation of possible adverse effects and with pertinent …

Introduction: Topiramate (TOP) blocks glutamate receptors and facilitates GABA (γ-
aminobutyric acid) neurotransmission, effects that may facilitate smoking cessation. We …

Abstract Objective Cardiovascular risk factors (CVRFs) and impulsivity are common in
bipolar disorder (BD), and CVRFs are also linked with impulsivity through a number of …

The burden of disease associated with the obesity epidemic shortens lives, and prevalence
is accelerating. As with other chronic diseases, improved outcomes are associated with …

Objective: To review the use of topiramate for the treatment of binge-eating disorder (BED)
associated with obesity. Data Sources: MEDLINE (1966–July 2006) and the Cochrane …

This brief review examines hyperphagia and associated weight gain as undesirable side
effects of psychiatric medications; exploring the scope of the problem, proposed …

Approved for the treatment of epilepsy and migraine prophylaxis, topiramate also acts as a
carbonic anhydrase inhibitor implying a potential role in the treatment of pseudotumor …