Adversity early in life is common and is a major risk factor for the onset of psychopathology.
Delineating the neurodevelopmental pathways by which early adversity affects mental …

Human brain development is influenced by early-life experiences, particularly during
sensitive periods, with impact on cognitive and emotional outcomes. Understanding how the …

Early exposure to psychosocial adversity is among the most potent predictors of depression.
Because depression commonly emerges prior to adulthood, we must consider the …

Although decades of research have shown associations between early caregiving adversity,
stress physiology and limbic brain volume (eg, amygdala, hippocampus), the developmental …

In humans, early-life adversity (ELA) such as trauma, poverty, and chaotic environment is
linked to increased risk of later-life emotional disorders including depression and substance …

Early-life adversity (ELA), often clinically referred to as “adverse childhood experiences
(ACE),” is the exposure to stress-inducing events in childhood that can result in poor health …

Early life stress (ELS) is a well-characterized risk factor for mood and anxiety disorders.
GABAergic microcircuits in the amygdala are critically implicated in anxiety; however …

Postpartum adversity is among the strongest predictors for the emergence of postpartum
depression (PPD) in humans and a translational risk factor employed in rodent models …

Environmentally appropriate social behavior is critical for survival across the lifespan. To
support this flexible behavior, the brain must rapidly perform numerous computations taking …

We have established experimental systems to assess the effects of early-life exposures to
antibiotics on the intestinal microbiota and gene expression in the brain. This model system …