While the majority of the cardiac myocyte death that makes up the final infarct occurs during
ischemia and the first few minutes of reperfusion, cell death does not stop there. In fact …

Ischaemia significantly affects the cellular homeostasis (sodium and calcium overload,
intracellular acidosis, swelling, cytoskeleton injuries, mitochondrial hypercalcaemia and …

The endothelium is vital to the proper functioning in the heart, in particular due to its
production of nitric oxide (NO) which regulates vascular tone. Damage to the endothelium …

Background The aim of this study was to evaluate the combination of a rapid intravenous
infusion of cold saline and endovascular hypothermia in a closed chest pig infarct model …

Background—Myocardial infarction (MI) triggers a systemic inflammatory response which
determines subsequent healing. Experimentally, cardiac positron emission tomography and …

Although mean platelet volume (MPV) is an independent correlate of impaired angiographic
reperfusion and 6-month mortality in ST-segment elevation myocardial infarction (STEMI) …

Background—The area at risk (AAR) is a key determinant of myocardial infarction (MI) size.
We investigated whether magnetic resonance imaging (MRI) measurement of AAR would be …

Abstract Mild hypothermia, 32–35° C, is very potent at reducing myocardial infarct size in
rabbits, dogs, sheep, pigs, and rats. The benefit is directly related to reduction in …

Significance: Myocardial ischemia/reperfusion (I/R) is an important complication of
reperfusion therapy for myocardial infarction (MI). It is a complex process involving metabolic …

Restoring blood flow after myocardial infarction (MI) is essential for survival of existing and
newly regenerated tissue. Endogenous vascular repair processes are deployed following …