Optimized treatment of ST-elevation myocardial infarction: the unmet need to target coronary microvascular obstruction as primary treatment goal to further improve …

G Niccoli, RA Montone, B Ibanez, H Thiele… - Circulation …, 2019 - Am Heart Assoc
Primary percutaneous coronary intervention is nowadays the preferred reperfusion strategy
for patients with acute ST-segment–elevation myocardial infarction, aiming at restoring …

[HTML][HTML] Ischemia/reperfusion injury following acute myocardial infarction: a critical issue for clinicians and forensic pathologists

M Neri, I Riezzo, N Pascale, C Pomara… - Mediators of …, 2017 - hindawi.com
Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality. Reperfusion
strategies are the current standard therapy for AMI. However, they may result in paradoxical …

Coronary microvascular obstruction in acute myocardial infarction

G Niccoli, G Scalone, A Lerman… - European heart …, 2016 - academic.oup.com
The success of a primary percutaneous intervention (PCI) in the setting of ST elevation
myocardial infarction depends on the functional and structural integrity of coronary …

[HTML][HTML] Role of albumin in the preservation of endothelial glycocalyx integrity and the microcirculation: a review

C Aldecoa, JV Llau, X Nuvials… - Annals of …, 2020 - annalsofintensivecare.springeropen …
The endothelial glycocalyx comprises a complex layer of membrane-bound proteoglycans,
secreted glycosaminoglycans, glycoproteins, glycolipids and bound plasma proteins such …

Myocardial no-reflow in humans

G Niccoli, F Burzotta, L Galiuto, F Crea - Journal of the American College of …, 2009 - jacc.org
In a variable proportion of patients presenting with ST-segment elevation myocardial
infarction, ranging from 5% to 50%, primary percutaneous coronary intervention achieves …

Effect of microvascular obstruction and intramyocardial hemorrhage by CMR on LV remodeling and outcomes after myocardial infarction: a systematic review and …

YS Hamirani, A Wong, CM Kramer… - JACC: Cardiovascular …, 2014 - jacc.org
The goal of this systematic analysis is to provide a comprehensive review of the current
cardiac magnetic resonance data on microvascular obstruction (MVO) and intramyocardial …

Coronary microembolization: from bedside to bench and back to bedside

G Heusch, P Kleinbongard, D Böse, B Levkau… - Circulation, 2009 - Am Heart Assoc
Coronary microembolization from the erosion or rupture of a vulnerable atherosclerotic
plaque occurs spontaneously in acute coronary syndromes and iatrogenically during …

[HTML][HTML] SIRT1 agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during ischemia and reperfusion

Y Han, W Sun, D Ren, J Zhang, Z He, J Fedorova… - Redox biology, 2020 - Elsevier
Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3)
inflammasome was emerged as a marker of metabolic dysregulation. We revealed that age …

Translating cardioprotection for patient benefit: position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology

DJ Hausenloy, HE Bøtker, G Condorelli… - Cardiovascular …, 2013 - academic.oup.com
Coronary heart disease (CHD) is the leading cause of death and disability worldwide.
Despite current therapy, the morbidity and mortality for patients with CHD remains …

Endothelial mitochondria: contributing to vascular function and disease

SM Davidson, MR Duchen - Circulation research, 2007 - Am Heart Assoc
Disturbances in vascular function contribute to the development of several diseases of
increasing prevalence and thereby contribute significantly to human mortality and morbidity …