Conventional cancer therapies suffer from severe off-target effects because most of them
target critical facets of cells that are generally shared by all rapidly proliferating cells. The …

Recent studies found that unbalanced copper homeostasis affect tumor growth, causing
irreversible damage. Copper can induce multiple forms of cell death, including apoptosis …

Cuproptosis is a new form of programmed cell death and exhibits enormous potential in
cancer treatment. However, reducing the undesirable Cu ion release in normal tissue and …

The current advancements in nanotechnology are as an outcome of the development of
engineered nanoparticles. Various metallic nanoparticles have been extensively explored …

Platinum-based chemotherapy is widely used to treat various cancers. However, exogenous
platinum is likely to cause severe side effects and drug resistance induced by upregulated …

Traditional anticancer treatments have several limitations, but cancer is still one of the
deadliest diseases. As a result, new anticancer drugs are required for the treatment of …

Disulfiram (DSF) has been used as an alcoholism drug for 70 years. Recently, it has
attracted increasing attention owing to the distinguished anticancer activity, which can be …

Cuproptosis is a newly identified form of cell death driven by copper. Recently, the role of
copper and copper triggered cell death in the pathogenesis of cancers have attracted …

Inducing cancer cell death has always been a research hotspot in life sciences. With the
continuous deepening and diversification of related research, the potential value of metal …

As an emerging cancer therapeutic target, non-apoptotic cell death such as ferroptosis,
necroptosis and pyroptosis, etc., has revealed significant potential in cancer treatment for …