Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disorder. It is caused
by loss-of-function mutations in the dystrophin gene. Currently, there is no cure. A highly …

Like the major theme of a Mozart concerto, the immense and pervasive extracellular matrix
drives each movement and ultimately closes the symphony, embracing a unique role as the …

In vivo studies represent an essential step in drug development and currently rely largely on
mice, yet limitations of mammalian models motivated the search for complementary …

The establishment of human induced pluripotent stem cells (hiPSCs) has enabled the
production of in vitro, patient-specific cell models of human disease. In vitro recreation of …

Duchenne muscular dystrophy (DMD) is caused by mutations in the gene encoding
dystrophin, which results in dysfunctional signaling pathways within muscle. Previously, we …

• Introduction• Mechanisms of miRNA‐mediated repression• miRNA regulatory network in
muscle‐Muscle‐specific miRNAs‐Non‐muscle‐specific miRNAs• miRNA signatures as …

Perlecan's developmental functions are difficult to dissect in placental animals because
perlecan disruption is embryonic lethal. In contrast to mammals, cardiovascular function is …

Wild-type zebrafish embryos swim away in response to tactile stimulation. By contrast,
relatively relaxed mutants swim slowly due to weak contractions of trunk muscles …

Muscular dystrophies (MD) are a heterogeneous group of genetic disorders that cause
muscle weakness, abnormal contractions and muscle wasting, often leading to premature …

Duchenne muscular dystrophy (DMD) is characterized in skeletal muscle by cycles of
myofiber necrosis and regeneration leading to loss of muscle fibers and replacement with …