Mechanisms of weight regain after weight loss—the role of adipose tissue

MA Van Baak, ECM Mariman - Nature Reviews Endocrinology, 2019 - nature.com
One of the biggest challenges in the management of obesity is the prevention of weight
regain after successful weight loss. Weight regain after weight loss has large interindividual …

Omega-3 fatty acids and adipose tissue biology

O Kuda, M Rossmeisl, J Kopecky - Molecular Aspects of Medicine, 2018 - Elsevier
This review provides evidence for the importance of white and brown adipose tissue (ie WAT
and BAT) function for the maintenance of healthy metabolic phenotype and its preservation …

Moderate-intensity exercise and high-intensity interval training affect insulin sensitivity similarly in obese adults

BJ Ryan, MW Schleh, C Ahn, AC Ludzki… - The Journal of …, 2020 - academic.oup.com
Objective We compared the effects of high-intensity interval training (HIIT) and moderate-
intensity continuous training (MICT) on insulin sensitivity and other important metabolic …

Metabolic dysfunction in obesity is related to impaired suppression of fatty acid release from adipose tissue by insulin

MW Schleh, BJ Ryan, C Ahn, AC Ludzki, P Varshney… - …, 2023 - Wiley Online Library
Objective The aims of this study were: 1) to assess relationships among insulin‐mediated
glucose uptake with standard clinical outcomes and deep‐phenotyping measures (including …

The metabolic dysfunction of white adipose tissue induced in mice by a high-fat diet is abrogated by co-administration of docosahexaenoic acid and hydroxytyrosol

P Illesca, R Valenzuela, A Espinosa, F Echeverría… - Food & function, 2020 - pubs.rsc.org
Background: Nutritional interventions are promising tools for the prevention of obesity. The n-
3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) docosahexaenoic acid (DHA) …

Pathogenesis and remission of type 2 diabetes: what has the twin cycle hypothesis taught us?

A Al-Mrabeh - Cardiovascular Endocrinology & Metabolism, 2020 - journals.lww.com
Type 2 diabetes has been regarded a complex multifactorial disease that lead to serious
health complications including high cardiovascular risks. The twin cycle hypothesis …

[HTML][HTML] LIFR-α-dependent adipocyte signaling in obesity limits adipose expansion contributing to fatty liver disease

T Guo, A Gupta, J Yu, JZ Granados, AY Gandhi… - iscience, 2021 - cell.com
The role of chronic adipose inflammation in diet-induced obesity (DIO) and its sequelae
including fatty liver disease remains unclear. Leukemia inhibitory factor (LIF) induces JAK …

Challenges and opportunities in obesity: the role of adipocytes during tissue fibrosis

Q Zhang, C Lu, F Lu, Y Liao, J Cai, J Gao - Frontiers in Endocrinology, 2024 - frontiersin.org
Obesity is a chronic disease that affects the energy balance of the whole body. In addition to
increasing fat mass, tissue fibrosis occurred in white adipose tissue in obese condition …

Plasma ferritin concentration is positively associated with in vivo fatty acid mobilization and insulin resistance in obese women

BJ Ryan, DW Van Pelt, LM Guth… - Experimental …, 2018 - Wiley Online Library
New Findings What is the central question of this study? Do obese women with relatively
high whole‐body iron stores exhibit elevated in vivo rates of fatty acid (FA) release from …

Association of the PNPLA2, SCD1 and leptin expression with fat distribution in liver and adipose tissue from obese subjects

L De la Cruz-Color… - Experimental and …, 2020 - thieme-connect.com
The expansion of adipose tissue is regulated by insulin and leptin through sterol regulatory
element-binding protein-1c (SREBP-1c), up-regulating lipogenesis in tissues by …