Cancer-associated fibroblasts (CAFs) are major components of the surrounding stroma of
carcinomas that emerge in the tumor microenvironment as a result of signals derived from …

Simple Summary Cancer cells rely on the surrounding environment to grow and spread.
This environment contains structural components, secreted factors, immune cells, and other …

The preclinical drug screening of pancreatic cancer treatments suffers from the absence of
appropriate models capable to reproduce in vitro the heterogeneous tumor …

The ever-growing perception of cancer stem cells (CSCs) as a plastic state rather than a
hardwired defined entity has evolved our understanding of the functional and biological …

Pancreatic cancer (pancreatic ductal adenocarcinoma (PDAC/PC)) has been an aggressive
disease that is associated with early metastases. It is characterized by dense and …

Metastasis is the major cause of death in colorectal cancer (CRC) patients. Inhibition of
metastasis will prolong the survival of patients with CRC. Cancer cells bring their own soil …

Mucins are heavily glycosylated proteins that play critical roles in the pathogenesis of
tumour malignancies. Pancreatic ductal adenocarcinoma (PDAC) is characterised by the …

Simple Summary Pancreatic cancer is a leading cause of cancer death worldwide. In the
majority of patients, cancers are diagnosed at advanced stages of disease and are resistant …

Background: Pancreatic cancer is one of the malignant tumors that threaten human health.
Methods: The gene expression profiles of GSE15471, GSE19650, GSE32676 and …

Pancreatic cancer (PC) continues to pose a major clinical challenge. There has been little
improvement in patient survival over the past few decades, and it is projected to become the …