An update on the regulatory mechanisms of NLRP3 inflammasome activation
Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions
X Dong-Chen, C Yong, X Yang, ST Chen-Yu… - Signal transduction and …, 2023 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …
Targeting microglial α-synuclein/TLRs/NF-kappaB/NLRP3 inflammasome axis in Parkinson's disease
Y Li, Y Xia, S Yin, F Wan, J Hu, L Kou, Y Sun… - Frontiers in …, 2021 - frontiersin.org
According to emerging studies, the excessive activation of microglia and the subsequent
release of pro-inflammatory cytokines play important roles in the pathogenesis and …
release of pro-inflammatory cytokines play important roles in the pathogenesis and …
Integrating spatial and single-nucleus transcriptomic data elucidates microglial-specific responses in female cynomolgus macaques with depressive-like behaviors
J Wu, Y Li, Y Huang, L Liu, H Zhang, C Nagy… - Nature …, 2023 - nature.com
Major depressive disorder represents a serious public health challenge worldwide;
however, the underlying cellular and molecular mechanisms are mostly unknown. Here, we …
however, the underlying cellular and molecular mechanisms are mostly unknown. Here, we …
Periphery and brain, innate and adaptive immunity in Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disorder where alpha-synuclein plays a
central role in the death and dysfunction of neurons, both, in central, as well as in the …
central role in the death and dysfunction of neurons, both, in central, as well as in the …
[HTML][HTML] Microglia and astrocyte dysfunction in parkinson's disease
While glia are essential for regulating the homeostasis in the normal brain, their dysfunction
contributes to neurodegeneration in many brain diseases, including Parkinson's disease …
contributes to neurodegeneration in many brain diseases, including Parkinson's disease …
Biomarker of neuroinflammation in Parkinson's disease
TW Liu, CM Chen, KH Chang - International journal of molecular sciences, 2022 - mdpi.com
Parkinson's disease (PD) is caused by abnormal accumulation of α-synuclein in
dopaminergic neurons of the substantia nigra, which subsequently causes motor symptoms …
dopaminergic neurons of the substantia nigra, which subsequently causes motor symptoms …
Parkinson disease and the immune system—associations, mechanisms and therapeutics
Multiple lines of evidence indicate that immune system dysfunction has a role in Parkinson
disease (PD); this evidence includes clinical and genetic associations between autoimmune …
disease (PD); this evidence includes clinical and genetic associations between autoimmune …
Inflammasome assembly in neurodegenerative diseases
J Singh, ML Habean, N Panicker - Trends in Neurosciences, 2023 - cell.com
Neurodegenerative disorders are characterized by the progressive dysfunction and death of
selectively vulnerable neuronal populations, often associated with the accumulation of …
selectively vulnerable neuronal populations, often associated with the accumulation of …
Neurodegenerative disease and the NLRP3 inflammasome
JA Holbrook, HH Jarosz-Griffiths, E Caseley… - Frontiers in …, 2021 - frontiersin.org
The prevalence of neurodegenerative disease has increased significantly in recent years,
and with a rapidly aging global population, this trend is expected to continue. These …
and with a rapidly aging global population, this trend is expected to continue. These …