Visible-to-NIR-light activated release: from small molecules to nanomaterials
Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable)
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …
Dissecting the role of protein phosphorylation: a chemical biology toolbox
Protein phosphorylation is a crucial regulator of protein and cellular function, yet, despite
identifying an enormous number of phosphorylation sites, the role of most is still unclear …
identifying an enormous number of phosphorylation sites, the role of most is still unclear …
[PDF][PDF] In vitro and in vivo uncaging and bioluminescence imaging by using photocaged upconversion nanoparticles
High temporal and spatial regulation of cellular activities, biological pathways, and gene
expression is critical in complex biological processes.[1] One remarkable technique that …
expression is critical in complex biological processes.[1] One remarkable technique that …
Light-triggered release of photocaged therapeutics-Where are we now?
The current available therapeutics face several challenges such as the development of ideal
drug delivery systems towards the goal of personalized treatments for patients benefit. The …
drug delivery systems towards the goal of personalized treatments for patients benefit. The …
Illuminating the chemistry of life: design, synthesis, and applications of “caged” and related photoresponsive compounds
Biological systems are characterized by a level of spatial and temporal organization that
often lies beyond the grasp of present day methods. Light-modulated bioreagents, including …
often lies beyond the grasp of present day methods. Light-modulated bioreagents, including …
Applications of p-hydroxyphenacyl (p HP) and coumarin-4-ylmethyl photoremovable protecting groups
RS Givens, M Rubina, J Wirz - Photochemical & Photobiological …, 2012 - pubs.rsc.org
Most applications of photoremovable protecting groups have used o-nitrobenzyl compounds
and their (often commercially available) derivatives that, however, have several …
and their (often commercially available) derivatives that, however, have several …
Extensive reprogramming of the genetic code for genetically encoded synthesis of highly N-alkylated polycyclic peptidomimetics
T Kawakami, T Ishizawa… - Journal of the American …, 2013 - ACS Publications
Cyclic structures can increase the proteolytic stability and conformational rigidity of peptides,
and N-alkylation of the peptide backbone can make peptides more cell-permeable and …
and N-alkylation of the peptide backbone can make peptides more cell-permeable and …
One-step construction of caged carbonic anhydrase I using a ligand-directed acyl imidazole-based protein labeling method
Caged enzymes whose activities can be controlled by light represent a powerful tool for
various biological analyses. However, limited methods are available for the construction of …
various biological analyses. However, limited methods are available for the construction of …
Development and photo-responsive peptide bond cleavage reaction of two-photon near-infrared excitation-responsive peptide
A Shigenaga, J Yamamoto, Y Sumikawa, T Furuta… - Tetrahedron …, 2010 - Elsevier
Two-photon near-infrared excitation-responsive amino acid was developed. It was
incorporated into a peptide, and focused near-infrared pulsed laser irradiation-induced …
incorporated into a peptide, and focused near-infrared pulsed laser irradiation-induced …
Photocontrol of biological activities of protein by means of a hydrogel
S Murayama, M Kato - Analytical chemistry, 2010 - ACS Publications
Because proteins show high activity and are essential for biological function, proteins are
important and useful biomolecules; however, it is hard to control activities whenever and …
important and useful biomolecules; however, it is hard to control activities whenever and …