Environmental modifiable risk factors for multiple sclerosis: Report from the 2016 ECTRIMS focused workshop

MP Amato, T Derfuss, B Hemmer… - Multiple Sclerosis …, 2018 - journals.sagepub.com
Multiple sclerosis (MS) is an inflammatory and neurodegenerative demyelinating disease of
the central nervous system (CNS), most likely autoimmune in origin, usually beginning in …

The evidence for a role of B cells in multiple sclerosis

G Disanto, JM Morahan, MH Barnett, G Giovannoni… - Neurology, 2012 - AAN Enterprises
Understanding the pathogenesis of complex immunologic disorders such as multiple
sclerosis (MS) is challenging. Abnormalities in many different cell types are observed in the …

A review of genome-wide association studies for multiple sclerosis: classical and hypothesis-driven approaches

VV Bashinskaya, OG Kulakova, AN Boyko, AV Favorov… - Human genetics, 2015 - Springer
Multiple sclerosis (MS) is a common complex neurodegenerative disease of the central
nervous system. It develops with autoimmune inflammation and demyelination. Genome …

[HTML][HTML] Impact of B cells to the pathophysiology of multiple sclerosis

BM Arneth - Journal of Neuroinflammation, 2019 - Springer
Introduction Multiple sclerosis (MS) is a chronic autoimmune disorder that affects the central
nervous system and compromises the health and well-being of millions of people worldwide …

Bioinformatic processes for determination of peptide binding

RD Bremel, J Homan - 2013 - Google Patents
This invention relates to the identification of peptide binding to ligands, and in particular to
identification of epitopes expressed by microorganisms and by mammalian cells. The …

Heterogeneity in multiple sclerosis: scratching the surface of a complex disease

G Disanto, AJ Berlanga, AE Handel… - Autoimmune …, 2011 - Wiley Online Library
Multiple Sclerosis (MS) is the most common demyelinating disease of the central nervous
system. Although the etiology and the pathogenesis of MS has been extensively …

Epstein–Barr virus and multiple sclerosis. From evidence to therapeutic strategies

S Fernández-Menéndez, M Fernández-Morán… - Journal of the …, 2016 - Elsevier
Multiple sclerosis is caused by a complex interaction between genetic predisposition and
environmental factors. Epstein–Barr virus (EBV) is an environmental risk factor that is …

Multiple sclerosis: risk factors and their interactions

G Disanto, JM Morahan… - CNS & Neurological …, 2012 - ingentaconnect.com
Multiple sclerosis (MS) is a highly debilitating immune mediated disorder of the central
nervous system and represents a substantial burden to the developed world. Despite the …

[HTML][HTML] HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders

S Le Clerc, L Lombardi, BT Baune, AT Amare… - Scientific reports, 2021 - nature.com
Bipolar affective disorder (BD) is a severe psychiatric illness, for which lithium (Li) is the gold
standard for acute and maintenance therapies. The therapeutic response to Li in BD is …

The role of epigenetic mechanisms and processes in autoimmune disorders

JM Greer, PA McCombe - Biologics: Targets and Therapy, 2012 - Taylor & Francis
The lack of complete concordance of autoimmune disease in identical twins suggests that
nongenetic factors play a major role in determining disease susceptibility. In this review, we …