Fungal proteases as emerging biocatalysts to meet the current challenges and recent developments in biomedical therapies: an updated review

M Naeem, S Manzoor, MUH Abid, MBK Tareen… - Journal of Fungi, 2022 - mdpi.com
With the increasing world population, demand for industrialization has also increased to
fulfill humans' living standards. Fungi are considered a source of essential constituents to …

Protease inhibitors from plants as therapeutic agents-a review

MS Cid-Gallegos, LJ Corzo-Ríos… - Plant Foods for Human …, 2022 - Springer
Plant-based diets are a great source of protease inhibitors (PIs). Two of the most well-known
families of PIs are Bowman-Birk inhibitors (BBI) and Kunitz-type inhibitors (KTI). The first …

Bowman-Birk inhibitors: Insights into family of multifunctional proteins and peptides with potential therapeutical applications

A Gitlin-Domagalska, A Maciejewska, D Dębowski - Pharmaceuticals, 2020 - mdpi.com
Bowman-Birk inhibitors (BBIs) are found primarily in seeds of legumes and in cereal grains.
These canonical inhibitors share a highly conserved nine-amino acids binding loop motif …

Rational design of hyperstable antibacterial peptides for food preservation

YL Vishweshwaraiah, A Acharya, V Hegde… - npj Science of …, 2021 - nature.com
We describe the design of peptides with properties like thermostability, pH stability, and
antibacterial activity against a few bacterial food pathogens. Insights obtained from classical …

Serpins in tick physiology and tick-host interaction

MN Abbas, A Chlastáková, MA Jmel… - Frontiers in Cellular …, 2022 - frontiersin.org
Tick saliva has been extensively studied in the context of tick-host interactions because it is
involved in host homeostasis modulation and microbial pathogen transmission to the host …

Current status and perspectives of protease inhibitors and their combination with nanosized drug delivery systems for targeted cancer therapy

M Rudzińska, C Daglioglu, LV Savvateeva… - Drug design …, 2021 - Taylor & Francis
In cancer treatments, many natural and synthetic products have been examined; among
them, protease inhibitors are promising candidates for anti-cancer agents. Since …

Intestinal exposure to food-derived protease inhibitors: digestion physiology-and gut health-related effects

A Kårlund, I Paukkonen, C Gómez-Gallego… - Healthcare, 2021 - mdpi.com
Plant-derived protease inhibitors (PI), such as Bowman-Birk inhibitors and Kunitz-type
inhibitors, have been suggested to negatively affect dietary protein digestion by blocking the …

Anti-nutritional factors and bioavailability: Approaches, challenges, and opportunities

S Ram, S Narwal, OP Gupta, V Pandey… - Wheat and barley grain …, 2020 - Elsevier
Antinutritional factors are deleterious compounds present in the grain which interfere with
the absorption of biomolecules and hamper their bioavailability to the human beings and …

The forgotten 2S albumin proteins: Importance, structure, and biotechnological application in agriculture and human health

PFN Souza - International Journal of Biological Macromolecules, 2020 - Elsevier
Abstract 2S albumin proteins are a group of important seed storage proteins (SSPs)
essential to seeds at early and late developmental stages, by providing amino acids and …

Combined omics approaches expose metabolite-microbiota correlations in grape berries of three cultivars of Douro wine region

V Martins, A Szakiel, A Teixeira, C Abdallah, C Moreira… - Food Chemistry, 2023 - Elsevier
This study hypothesized the existence of cultivar-associated correlations between grape
berry metabolites and its microbial residents, in Douro wine region. Integrated metabolomics …