[HTML][HTML] Methylphenidate alleviates cognitive dysfunction caused by early manganese exposure: Role of catecholaminergic receptors

SA Beaudin, S Howard, N Santiago, BJ Strupp… - Progress in Neuro …, 2024 - Elsevier
Environmental manganese (Mn) exposure is associated with impaired attention and
psychomotor functioning, as well as impulsivity/hyperactivity in children and adolescents …

Invited Perspective: Studying Metal Impacts on Neurobehavior during the Critical but Challenging Window of Adolescence

CG Howe, HE Laue - Environmental Health Perspectives, 2024 - ehp.niehs.nih.gov
An additional layer of complexity in studying attention during adolescence is the potential for
discrepancies in measures of attention across raters. This was highlighted in the study by …

Maternal choline supplementation lessens the behavioral dysfunction produced by developmental manganese exposure in a rodent model of ADHD

SL Howard, SA Beaudin, BJ Strupp… - Neurotoxicology and …, 2024 - Elsevier
Studies in children have reported associations between elevated manganese (Mn)
exposure and ADHD-related symptoms of inattention, impulsivity/hyperactivity, and …

Interaction of prenatal maternal selenium and manganese levels on child neurodevelopmental trajectories-the Shanghai birth cohort study

X Guo, J Xu, Y Tian, F Ouyang, X Yu, J Liu… - Science of The Total …, 2024 - Elsevier
Objective The fetal brain is particularly plastic, and may be concurrently affected by chemical
exposure and malnutritional factors. Selenium is essential for the developing brain, and …

Sensorimotor dysfunction due to developmental manganese exposure is less severe in adult female than male rats and partially improved by acute methylphenidate …

SA Beaudin, S Gorman, N Schilpp, D Woodfin… - Neurotoxicology and …, 2024 - Elsevier
Epidemiological studies have reported associations between elevated manganese (Mn)
exposure and poorer psychomotor performance in children. Our studies in adult male rats …

[HTML][HTML] Association between autism spectrum disorder, trace elements, and intracranial fluid spaces

M Mlinarič, M Jekovec Vrhovšek, D Neubauer… - International journal of …, 2024 - mdpi.com
(1) Autism spectrum disorder (ASD) belongs to the group of complex developmental
disorders. Novel studies have suggested that genetic and environmental factors equally …

[HTML][HTML] Methylphenidate alleviates cognitive dysfunction from early Mn exposure: Role of catecholaminergic receptors

SA Beaudin, S Howard, N Santiago, BJ Strupp… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Environmental manganese (Mn) exposure is associated with impaired attention and
psychomotor functioning, as well as impulsivity/hyperactivity in children and adolescents …

Methylphenidate alleviates attentional and sensorimotor dysfunction induced by developmental manganese exposure: Assessment of catecholaminergic receptor …

SA Beaudin, S Howard, N Santiago, BJ Strupp… - bioRxiv, 2023 - biorxiv.org
BACKGROUND Environmental manganese (Mn) exposure is associated with impairments
in attention and psychomotor function as well as impulsivity/hyperactivity in children and …

Developmental manganese exposure causes lasting attention deficits accompanied by dysregulation of mTOR signaling and catecholaminergic gene expression in …

NA Santiago, B He, SL Howard, S Beaudin, BJ Strupp… - BioRxiv, 2023 - biorxiv.org
Elevated manganese (Mn) exposure is associated with attentional deficits in children, and is
an environmental risk factor for attention deficit hyperactivity disorder (ADHD). We have …

A New Look at Animal Models of Neurological Disorders

MF Chesselet - Neurotherapeutics, 2023 - Springer
The impact of animal models of neurological disorders remains hotly debated, the main
point of contention being the frequent clinical failure of therapies successfully tested in …