Neuro-ethological studies conducted by Panksepp and his colleagues have provided an
understanding of how the activity of the mesolimbic dopaminergic (ML DA) system leads to …

Most people accessing mental health services have adverse childhood experiences (ACEs)
and/or histories of complex trauma. In recognition of this, there are calls to move away from …

Environmental Enrichment (EE) is based on the promotion of socio-environmental stimuli,
which mimic favorable environmental conditions for the practice of physical activity and …

Resilience and vulnerability to neuropsychiatric disorders are linked to molecular changes
underlying excitability that are still poorly understood. Here, we identify glycogen-synthase …

The pre-and post-natal periods are characterized by unrivalled growth and are sensitive to
environmental changes. A correctly stimulating early environment is essential for developing …

Neuroinflammation is discussed to play a role in specific subgroups of different psychiatric
disorders, including anxiety disorders. We have previously shown that a mouse model of …

Environment is known to substantially alter mental state and behaviour across the lifespan.
Biological barriers such as the blood–brain barrier (BBB) and gut barrier (GB) are major …

Highlights•EE produces beneficial effects on psychiatric disorders including addiction.•The
effects of EE on the brain may inspire the development of new medications.•'Enviromimetics' …

To study how motivational factors modulate experience-dependent neurobehavioral
plasticity, we modify a protocol of environmental enrichment (EE) in rats. We assumed that …

'What doesn't kill you makes you stronger'. Hormesis, the paradoxical beneficial effects of
low-dose stressors, can be better defined as the biphasic dose–effect or time–effect …