Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

Inflammatory dermatosis is characterized by persistent inflammatory infiltration and hard
repair of diseased skin. As a member of the human innate immune cells, macrophages …

Fibrosis is the excessive deposition of a stable extracellular matrix (ECM); fibrotic tissue is
composed principally of highly crosslinked type I collagen and highly contractile …

Immune cells are fundamental regulators of extracellular matrix (ECM) production by
fibroblasts and have important roles in determining extent of fibrosis in response to …

Systemic sclerosis (SSc) is a complex disease that affects the connective tissue, causing
fibrosis. SSc patients show altered immune cell composition and activation in the peripheral …

The macrophage is an essential part of the innate immune system and also serves as the
bridge between innate immunity and adaptive immune response. As the initiator and …

Systemic sclerosis (SSc) is an intricate systemic autoimmune disease with pathological
features such as vascular injury, immune dysregulation, and extensive fibrosis of the skin …

There is increasing evidence implicating cellular senescence in SSc. The mechanisms
underlying premature cellular senescence in SSc, and its potential role in pathogenesis …

Systemic sclerosis (also called scleroderma, SSc) is a chronic autoimmune disorder
characterized by excessive collagen deposition leading to skin fibrosis and various internal …

Vasculogenic mimicry (VM) describes the ability of highly aggressive tumor cells to develop
pseudovascular structures without the participation of endothelial cells. PARP1 is implicated …