Protein aggregation is common to dozens of diseases including prionoses, diabetes,
Parkinson's and Alzheimer's. Over the past 15 years, there has been a paradigm shift in …

Physical activity plays an essential role in maintaining a healthy body, yet it also provides
unique benefits for the vascular and cellular systems that sustain a healthy brain. While the …

NMDA receptor (NMDAR)-induced excitotoxicity is thought to contribute to the cell death
associated with certain neurodegenerative diseases, stroke, epilepsy, and traumatic brain …

Globally, neurodegenerative diseases cause a significant degree of disability and distress.
Brain-derived neurotrophic factor (BDNF), primarily found in the brain, has a substantial role …

BDNF/TrkB neurotrophic signaling regulates neuronal development, differentiation, and
survival, and deficient BDNF/TrkB activity underlies neurodegeneration in Alzheimer's …

Brain plasticity refers to the remarkable property of cerebral neurons to change their
structure and function in response to experience, a fundamental theoretical theme in the …

Epidemiological, neuropathological, and functional neuroimaging evidence implicates
global and regional disruptions in brain metabolism and energetics in the pathogenesis of …

Alzheimer's disease (AD) is the 3rd most costly disease and the leading cause of dementia.
It can linger for many years, but ultimately is fatal, the 6th leading cause of death …

Introduction• Protein aggregation‐'Toxic oligomer'hypothesis‐Protein (mis) folding‐
Proteostasis and molecular chaperones‐Protein misfolding and endoplasmic reticulum …

Neurotrophic factors comprise essential secreted proteins that have several functions in
neural and non-neural tissues, mediating the development, survival and maintenance of …