[HTML][HTML] Seventy years of Chlamydia vaccine research–limitations of the past and directions for the future

S Phillips, BL Quigley, P Timms - Frontiers in microbiology, 2019 - frontiersin.org
Chlamydia is a major bacterial pathogen that infects humans, as well as a wide range of
animals, including marsupials, birds, cats, pigs, cattle, and sheep. Antibiotics are the only …

Update on Chlamydia trachomatis vaccinology

LM de la Maza, G Zhong… - Clinical and Vaccine …, 2017 - Am Soc Microbiol
Attempts to produce a vaccine to protect against Chlamydia trachomatis-induced trachoma
were initiated more than 100 years ago and continued for several decades. Using whole …

Genital Chlamydia trachomatis: understanding the roles of innate and adaptive immunity in vaccine research

S Vasilevsky, G Greub… - Clinical microbiology …, 2014 - Am Soc Microbiol
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted disease
worldwide, and despite significant advances in chlamydial research, a prophylactic vaccine …

Evaluation of tandem Chlamydia trachomatis MOMP multi-epitopes vaccine in BALB/c mice model

P Jiang, Y Cai, J Chen, X Ye, S Mao, S Zhu, X Xue… - Vaccine, 2017 - Elsevier
Chlamydia trachomatis (Ct), an obligate intracellular parasite, is the leading cause of
bacterial sexually transmitted diseases worldwide. The best solution to control the spread of …

Vaccination against Chlamydia Genital Infection Utilizing the Murine C. muridarum Model

CM Farris, RP Morrison - Infection and immunity, 2011 - Am Soc Microbiol
Chlamydia trachomatis genital infection is a worldwide public health problem, and
considerable effort has been expended on developing an efficacious vaccine. The murine …

CD4+ T Cells and Antibody Are Required for Optimal Major Outer Membrane Protein Vaccine-Induced Immunity to Chlamydia muridarum Genital Infection

CM Farris, SG Morrison, RP Morrison - Infection and immunity, 2010 - Am Soc Microbiol
Despite effective antimicrobial chemotherapy, control of Chlamydia trachomatis urogenital
infection will likely require a vaccine. We have assessed the protective effect of an outer …

A modular vaccine platform enabled by decoration of bacterial outer membrane vesicles with biotinylated antigens

KB Weyant, A Oloyede, S Pal, J Liao… - Nature …, 2023 - nature.com
Engineered outer membrane vesicles (OMVs) derived from Gram-negative bacteria are a
promising technology for the creation of non-infectious, nanoparticle vaccines against …

A Chlamydia trachomatis VD1-MOMP vaccine elicits cross-neutralizing and protective antibodies against C/C-related complex serovars

AW Olsen, I Rosenkrands, MJ Holland, P Andersen… - npj Vaccines, 2021 - nature.com
Ocular and urogenital infections with Chlamydia trachomatis (Ct.) are caused by a range of
different serovars. The first Ct. vaccine in clinical development (CTH522/CAF® 01) induced …

A re-evaluation of the role of B cells in protective immunity to Chlamydia infection

LX Li, SJ McSorley - Immunology letters, 2015 - Elsevier
Chlamydia trachomatis is the etiological agent of the most commonly reported bacterial
sexual transmitted infection (STI) in North America and Europe. The control of Chlamydia …

Vaccination of healthy and diseased koalas (Phascolarctos cinereus) with a Chlamydia pecorum multi-subunit vaccine: evaluation of immunity and pathology

A Kollipara, C George, J Hanger, J Loader… - Vaccine, 2012 - Elsevier
Chlamydial infections represent a major threat to the long-term survival of the koala and a
successful vaccine would provide a valuable management tool. Vaccination however has …