Head and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is
characterized by high morbidity and low survival rates with limited therapeutic options …

Notch signalling is involved in many aspects of cancer biology, including angiogenesis,
tumour immunity and the maintenance of cancer stem-like cells. In addition, Notch can …

Immunosurveillance is a critical mechanism guarding against tumor development and
progression. Checkpoint inhibitors have shown significant success in cancer treatment, but …

Cancer stem cells (CSCs), also known as tumor‐initiating cells (TICs), are suggested to be
responsible for drug resistance and cancer relapse due in part to their ability to self‐renew …

Background Cancer cells selectively promote the translation of oncogenic transcripts to
stimulate cancer progression. Although growing evidence has revealed that tRNA …

Tumor microenvironment (TME) takes critical roles in tumor resistance to immune checkpoint
inhibitors (ICIs) including anti-programmed death-1 (PD-1) or anti-programmed death-ligand …

Background Accumulating evidence indicates that circular RNAs (circRNAs) act as
microRNA (miRNA) sponges to directly inhibit specific miRNAs and alter their ability to …

Cancer stem cells (CSCs) play a critical role in invasive growth and metastasis of human
head and neck squamous cell carcinoma (HNSCC). Although significant progress has been …

Although immunotherapy has revolutionized oncotherapy, only≈ 15% of head and neck
squamous cell carcinoma (HNSCC) patients benefit from the current therapies. An …

Cancer stemness and immune evasion are closely associated, and play critical roles in
tumor development and resistance to immunotherapy. However, little is known about the …