The year 2017 marks the twentieth anniversary of terpenoid cyclase structural biology: a trio
of terpenoid cyclase structures reported together in 1997 were the first to set the foundation …

Gossypol is a phenolic compound produced by pigment glands in cotton stems, leaves,
seeds, and flower buds (Gossypium spp.). Cottonseed meal is a by‐product of cotton that is …

Fibrosis is the final pathological outcome and major cause of morbidity and mortality in many
common and chronic inflammatory, immune-mediated, and metabolic diseases. Despite the …

Androgen-independent metastatic prostate cancer is the main obstacle in the treatment of
this cancer. Unlike a majority of solid cancers, prostate cancer usually shows poor response …

Among the most promising chemopreventive agents, certain natural polyphenols have
recently received a great deal of attention because of their demonstrated inhibitory activity …

Gossypol, a male contraceptive drug, has been demonstrated to have antiproliferative and
antimetastatic effects on many kinds of cancer cells in vitro. HT-29 human carcinoma cell …

Lanostanoid triterpenes isolated from Ganoderma amboinense were found to inhibit the
growth of numerous cancer cell lines, and some of them inhibited the activities of …

Aberrant overexpression of antiapoptotic members of the Bcl-2 protein family, including Bcl-
2 and Bcl-XL, contributes to malignant transformation and subsequent resistance to …

Authored by a panel of experts in cell physiology, phytochemistry, ethnopharmacology,
applied botany, ethnobotany, and cosmetic science, this book demonstrates the science …

Abstract Antiapoptotic Bcl-2-family proteins Bcl-2 and Bcl-X L have been recently validated
as drug discovery targets for cancer. Here, by using a combination of molecular modeling …