Are cell-based therapies safe and effective in the treatment of neurodegenerative diseases? A systematic review with meta-analysis

J Van den Bos, YE Ouaamari, K Wouters, N Cools… - Biomolecules, 2022 - mdpi.com
Over the past two decades, significant advances have been made in the field of regenerative
medicine. However, despite being of the utmost clinical urgency, there remains a paucity of …

[HTML][HTML] Clinical results of neurorestorative cell therapies and therapeutic indications according to cellular bio-proprieties

H Huang, PR Sanberg, GA Moviglia, A Sharma… - Regenerative …, 2023 - Elsevier
Cell therapies have been explored to treat patients with nervous diseases for over 20 years.
Even though most kinds of cell therapies demonstrated neurorestorative effects in non …

[HTML][HTML] Multiple intracerebroventricular injections of human umbilical cord mesenchymal stem cells delay motor neurons loss but not disease progression of …

F Sironi, A Vallarola, MB Violatto, L Talamini… - Stem Cell Research, 2017 - Elsevier
Stem cell therapy is considered a promising approach in the treatment of amyotrophic lateral
sclerosis (ALS) and mesenchymal stem cells (MSCs) seem to be the most effective in ALS …

Monoclonal antibody‐mediated immunosuppression enables long‐term survival of transplanted human neural stem cells in mouse brain

LM McGinley, KS Chen, SN Mason… - Clinical and …, 2022 - Wiley Online Library
Background As the field of stem cell therapy advances, it is important to develop reliable
methods to overcome host immune responses in animal models. This ensures survival of …

Cell therapy for neurological disorders: The perspective of promising cells

D Liu, L Bobrovskaya, XF Zhou - Biology, 2021 - mdpi.com
Simple Summary Cell therapy has become a powerful method for regenerative medicine.
However, there has not been an ideal cell type and cell source for the treatment of …

The safety and efficacy of stem cell therapy as an emerging therapy for ALS: a systematic review of controlled clinical trials

A Aljabri, A Halawani, G Bin Lajdam, S Labban… - Frontiers in …, 2021 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a heterogeneous
course that ultimately leads to death. Currently, there is no cure, and new treatments that can …

Stem cell clinical trials in spinal cord injury: a brief review of studies in the United States

A Platt, BT David, RG Fessler - Medicines, 2020 - mdpi.com
Background: Although many therapeutic approaches have been attempted to treat spinal
cord injury, cellular transplantation offers the greatest promise in reconstituting the …

Immunosuppression in stem cell clinical trials of neural and retinal cell types: A systematic review

S Gowrishankar, ME Smith, N Creber, J Muzaffar… - Plos one, 2024 - journals.plos.org
Background Pharmacologic immunosuppression regimes are commonly employed in stem
cell clinical trials to mitigate host immune rejection and promote survival and viability of …

Highly feasible procedure for laparoscopic transplantation of cell sheets under pneumoperitoneum in porcine model

S Yamaguchi, K Kanetaka, Y Maruya, M Higashi… - Surgical …, 2022 - Springer
Introduction Cell sheet technology is one of the most successful methodologies in
regenerative medicine. Various applications of cell sheets have been introduced in first-in …

Human fetal neural stem cells for neurodegenerative disease treatment

D Ferrari, M Gelati, DC Profico, AL Vescovi - Human Neural Stem Cells …, 2018 - Springer
Clinical trials for Parkinson's disease, which used primary brain fetal tissue, have
demonstrated that neural stem cell therapy could be suitable for neurodegenerative …