Acquired chromosome aberrations are present in the marrow of most patients with acute
myeloid leukaemia (AML) at diagnosis. Cytogenetically, AML is a very heterogeneous …

Purpose Because both t (8; 21) and inv (16) disrupt core binding factor (CBF) in acute
myeloid leukemia (AML) and confer relatively favorable prognoses, these cytogenetic …

Relapsed or refractory pediatric acute myeloid leukemia (AML) is associated with poor
outcomes and relapse risk prediction approaches have not changed significantly in …

Cytogenetic analysis is the most important diagnostic tool for determining prognosis in acute
myeloid leukemia (AML). In the majority of patients with AML, acquired clonal chromosome …

To evaluate the prognostic significance of quantitative PML-RARA, AML1-ETO, and CBFB-
MYH11 fusion transcript expression, real-time polymerase chain reaction was used to …

Acute myeloid leukemia (AML) is a heterogeneous group of genetically defined diseases.
Their classification is important with regard to prognosis and treatment. We performed …

Results: Patients with AML M3, M3v, or M4eo demon-strated a better outcome compared
with all other FAB subtypes (P<. 001); no prognostic difference was observed among other …

BACKGROUND AND OBJECTIVES. Recent investigations in acute myeloid leukemia (AML)
have clearly demonstrated that specific karyotypic abnormalities result in distinct biological …

In routine diagnostic procedures of acute myeloid leukemia (AML), the French–American–
British (FAB) and World Health Organization (WHO) classifications both play a central role …

The t (8; 21) translocation, which encodes the AML1-ETO fusion protein (now known as
RUNX1-CBF2T1), is one of the most frequent translocations in acute myeloid leukemia …