Presence of specific chromosomal abnormalities is one of the most important prognostic
factors in acute myeloid leukemia (AML). Recent advances in molecular biology have …

The AML1 transcription factor, identified by the cloning of the translocation t (8; 21)
breakpoint, is one of the most frequent targets for chromosomal translocations in leukemia …

The 8; 21 chromosomal translocation occurs in 15% to 40% of patients with the FAB M2
subtype of acute myeloid leukemia (AML). This chromosomal abnormality fuses part of the …

Background: Acute myeloid leukemia (AML) cases with t (8; 21) or inv (16) have a favorable
outcome, but the associated prognoses are heterogeneous and complicated by additional …

Simple Summary The diagnostic assessment of eosinophilias is complex, requiring a
multidisciplinary approach and often involving diagnostic challenges. This work aims for a …

Cancer stem cells (CSCs) are widely acknowledged as the drivers of tumor initiation,
epithelial‐mesenchymal transition (EMT) progression, and metastasis. Originating from both …

Abstract The t (8; 21)(q22; q22) is the most common translocation in acute myeloid leukemia
(AML). We describe the clinicopathologic and cytogenetic profile of 117 patients with t (8; 21) …

New methods from molecular biology have the potential to change medicine fundamentally.
However, for the time being there is a substantial gap between fiction and clinical reality …

Myeloid leukemias are a broad group of hematological disorders, characterized by
heterogeneous clinical and biological features. In recent years, unprecedented genetic …

Acute myelogenous leukemia with t (8; 21) is a distinct clinicopathologic entity in which the
malignant myeloblasts display a characteristic pattern of surface antigen expression …