Brain alarm by self-extracellular nucleic acids: From neuroinflammation to neurodegeneration

R Kunze, S Fischer, HH Marti, KT Preissner - Journal of Biomedical …, 2023 - Springer
Neurological disorders such as stroke, multiple sclerosis, as well as the neurodegenerative
diseases Parkinson's or Alzheimer's disease are accompanied or even powered by danger …

microRNA as a therapeutic for ischemic stroke

R Todoran, SR Falcione, M Clarke, T Joy… - Neurochemistry …, 2023 - Elsevier
Abstract microRNA (miRNA) are important regulators of gene expression. miRNA have the
potential as a treatment to modulate genes, pathways and cells involved in ischemic stroke …

Gas6 promotes microglia efferocytosis and suppresses inflammation through activating Axl/Rac1 signaling in subarachnoid hemorrhage mice

J Tang, Y Jin, F Jia, T Lv, A Manaenko… - Translational stroke …, 2023 - Springer
Early brain injury (EBI) following subarachnoid hemorrhage (SAH) is characterized by rapid
development of neuron apoptosis and dysregulated inflammatory response. Microglia …

The mechanisms of minocycline in alleviating ischemic stroke damage and cerebral ischemia-reperfusion injury

K Zhao, P Wang, X Tang, N Chang, H Shi, L Guo… - European Journal of …, 2023 - Elsevier
Stroke is a group of diseases resulting from cerebral vascular rupture or obstruction and
subsequent brain blood circulation disorder, leading to rapid neurological deficits. Ischemic …

Advantages of nanocarriers for basic research in the field of traumatic brain injury

X Song, Y Zhang, Z Tang, L Du - Neural regeneration research, 2024 - journals.lww.com
A major challenge for the efficient treatment of traumatic brain injury is the need for
therapeutic molecules to cross the blood-brain barrier to enter and accumulate in brain …

[HTML][HTML] Argatroban promotes recovery of spinal cord injury by inhibiting the PAR1/JAK2/STAT3 signaling pathway

C Zhao, T Zhou, M Li, J Liu, X Zhao… - Neural Regeneration …, 2024 - journals.lww.com
Argatroban is a synthetic thrombin inhibitor approved by US Food and Drug Administration
for the treatment of thrombosis. However, whether it plays a role in the repair of spinal cord …

miR-181b promotes angiogenesis and neurological function recovery after ischemic stroke

LX Xue, LY Shu, HM Wang, KL Lu… - Neural regeneration …, 2023 - journals.lww.com
Promotion of new blood vessel formation is a new strategy for treating ischemic stroke. Non-
coding miRNAs have been recently considered potential therapeutic targets for ischemic …

Therapeutic potential and mechanisms of novel simple o-substituted isoflavones against cerebral ischemia reperfusion

SE Yang, JC Lien, CW Tsai, CR Wu - International Journal of Molecular …, 2022 - mdpi.com
Isoflavones have been widely studied and have attracted extensive attention in fields
ranging from chemotaxonomy and plant physiology to human nutrition and medicine …

[HTML][HTML] Single-nuclei RNA sequencing uncovers heterogenous transcriptional signatures in Parkinson's disease associated with nuclear receptor-related factor 1 …

PA Kambey, WY Liu, J Wu, B Bosco… - Neural Regeneration …, 2023 - journals.lww.com
Previous studies have found that deficiency in nuclear receptor-related factor 1 (Nurr1),
which participates in the development, differentiation, survival, and degeneration of …

[HTML][HTML] Exosomal OIP5-AS1 attenuates cerebral ischemia-reperfusion injury by negatively regulating TXNIP protein stability and inhibiting neuronal pyroptosis

Z Li, Y Pang, L Hou, X Xing, F Yu, M Gao… - International …, 2024 - Elsevier
Background Cerebral ischemia–reperfusion injury (CIRI) can cause neuronal apoptosis and
lead to irreversible brain injury. Numerous lncRNAs have been reported to play important …