P. aeruginosa continues to be a serious problem worlwide as a cause of respiratory tract
infections in selected populations. Microbiologic diagnosis remains difficult and plagued …

Breakpoints are the values used by clinical microbiology laboratories to interpret the results
of antimicrobial susceptibility testing (AST) and classify isolates as susceptible or resistant …

Piperacillin-tazobactam (PTZ) is one of the most common antibiotics administered to
hospitalized patients. Its broad activity against gram-negative, gram-positive, and anaerobic …

The primary objectives of this analysis were to determine which pharmacokinetic model
most accurately describes the elimination pathways for piperacillin in the presence of …

The activity of daptomycin (DAP) against methicillin-resistant Staphylococcus aureus
(MRSA) is enhanced in the presence of subinhibitory concentrations of antistaphylococcal β …

Objective To explore the effects of renal function estimated by measured creatinine
clearance (Cl CR) on trough serum concentration (C min) of piperacillin given to critically ill …

ABSTRACT CXA-101 is a novel antipseudomonal cephalosporin with enhanced activity
against Gram-negative organisms displaying various resistance mechanisms. This study …

TO THE EDITOR—In January 2023, the Clinical and Laboratory Standards Institute (CLSI)
revised the piperacillintazobactam (PTZ) interpretive criteria against Pseudomonas …

Study Objective. To compare the pharmacokinetic and pharmacodynamic profiles of two
dosing regimens for piperacillin‐tazobactam against commonly encountered pathogens …

A rapid and sensitive reverse phase HPLC (RP-HPLC) method for the simultaneous
quantitation of piperacillin and tazobactam in human plasma has been developed and …